Description

1,2-Dipalmitoyl-Sn-Glycero-3-Thiophosphocholine is a synthetic, high-purity phospholipid derivative where the phosphate oxygen is replaced by sulfur, creating a thiophosphate ester linkage. This structural modification confers unique chemical stability and reactivity, making it a critical intermediate for advanced research and pharmaceutical development. It is primarily utilized by scientists and manufacturers in liposome formulation, membrane biophysics studies, and the synthesis of novel drug delivery systems.

Application

• Lipid Nanoparticle (LNP) and Liposome Research: A key phospholipid component for constructing stable, functional liposomal carriers for mRNA, siRNA, and other nucleic acid delivery.
• Membrane Protein Studies: Used in the preparation of model membranes and bicelles to study protein-lipid interactions due to its defined acyl chain structure.
• Pharmaceutical Intermediates: Serves as a crucial synthetic building block for creating thiophosphocholine-labeled probes and targeted therapeutic agents.
• Bioconjugation and Probe Development: The thiophosphate group offers a handle for specific chemical modifications and labeling for diagnostic applications.
• Reference Standard: Employed as a high-purity analytical standard in quality control laboratories for lipid analysis and characterization.

Basic Information

Item	Details
Product Name	1,2-Dipalmitoyl-Sn-Glycero-3-Thiophosphocholine
CAS No.	82482-77-7
Molecular Formula	C40H82NO7PS
Molecular Weight	752.11 g/mol
Synonyms	DPPC-S; 1,2-Dipalmitoyl-sn-glycero-3-thiophosphocholine; Thiophosphatidylcholine, dipalmitoyl; 1,2-Dihexadecanoyl-sn-glycero-3-thiophosphocholine; sn-Glycero-3-phosphothiocholine, 1,2-dipalmitoyl; Dipalmitoyl thiophosphatidylcholine; 3-sn-Phosphatidylcholine, 1,2-dipalmitoyl, thio analog
EINECS	Contact for details

Quality Control

Our 1,2-Dipalmitoyl-Sn-Glycero-3-Thiophosphocholine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and mass spectrometry, to ensure it meets the exacting standards required for pharmaceutical research and development. Certificates of Analysis (COA) with full traceability are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) due to its hygroscopic and potentially oxidizable nature. Allow the sealed container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Solvent Residue (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.