Description

15-Hydroxyeicosatrienoic Acid (15-HETrE) is a specialized hydroxy fatty acid and a key metabolite in the arachidonic acid cascade, serving as a bioactive lipid mediator. This compound is of significant interest for research into inflammatory pathways, cellular signaling, and lipid metabolism. It is primarily utilized by researchers and developers in the pharmaceutical, biotechnology, and life science sectors for biochemical studies, drug discovery, and as a reference standard.

Application

• Biochemical Research: Used as a critical reference standard and reagent in studies of eicosanoid biology, lipoxygenase pathways, and inflammatory mediator synthesis.
• Pharmaceutical Development: Investigated for its role in cell signaling mechanisms relevant to inflammation, immune response, and potential therapeutic target identification.
• Cell Biology Studies: Employed in vitro to study its effects on cellular functions, including proliferation, differentiation, and apoptosis.
• Metabolic Pathway Analysis: A vital tool for elucidating the metabolism of polyunsaturated fatty acids and the production of downstream oxylipins.
• Diagnostic Assay Development: Used in the development and calibration of analytical methods, such as LC-MS/MS and ELISA, for detecting eicosanoids in biological samples.
• Academic Research: Serves as a fundamental compound in university and institutional labs for advancing knowledge in lipidomics and molecular pharmacology.

Basic Information

Product Name	15-Hydroxyeicosatrienoic Acid
CAS No.	82451-61-4
Molecular Formula	C20H32O3
Molecular Weight	320.47 g/mol
Synonyms	15-HETrE; 15(S)-HETrE; 15-Hydroxy-8,11,13-eicosatrienoic acid; 15-Hydroxy-8Z,11Z,13E-eicosatrienoic acid; (15S)-15-Hydroxyicosa-8,11,13-trienoic acid; 15-HETE (ambiguous, often refers to tetraene); 15-Lipoxygenase metabolite of Dihomo-γ-linolenic acid (DGLA); 15-Hydroxy-DGLA
EINECS	Contact for details

Quality Control

Our 15-Hydroxyeicosatrienoic Acid is produced and handled under strict quality protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles for manufacturing and can support regulatory documentation needs for preclinical research.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation. Keep away from strong oxidizers.

Specification

Item	Specification
Appearance	Colorless to pale yellow oil or solid
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95% (Area %)
Isomeric Purity (Stereoisomer)	≥ 90% (15S)
Solubility	Soluble in ethanol, DMSO, DMF; slightly soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.