Description

6-Keto Prostaglandin F1Alpha-D4 is a stable isotope-labeled analog of 6-keto Prostaglandin F1α, a primary metabolite of prostacyclin (PGI2). This compound is of critical importance as an internal standard in quantitative mass spectrometry, enabling precise measurement of endogenous eicosanoid levels in complex biological matrices. It is primarily needed by researchers and analytical laboratories in the pharmaceutical, biotechnology, and clinical diagnostics sectors for method development and validation.

Application

• Internal Standard for LC-MS/MS: Essential for the accurate quantification of endogenous 6-keto PGF1α in plasma, serum, urine, and tissue samples.
• Biomarker Research: Used in studies investigating cardiovascular disease, inflammation, and endothelial function where prostacyclin metabolism is a key pathway.
• Drug Metabolism & Pharmacokinetics (DMPK): Employed in preclinical and clinical studies to track the metabolic fate of prostacyclin analogs or related therapeutics.
• Eicosanoid Profiling: A critical component in targeted metabolomics panels for comprehensive analysis of oxylipin and prostaglandin pathways.
• Quality Control Reference: Serves as a certified reference material (CRM) for assay calibration and ensuring the reliability of diagnostic test kits.

Basic Information

Product Name	6-Keto Prostaglandin F1Alpha-D4
CAS No.	82414-64-0
Molecular Formula	C₂₀H₂₈D₄O₆
Molecular Weight	372.48 g/mol
Synonyms	6-Keto-PGF1α-d4; 6-Keto-prostaglandin F1α-d4; 9α,11α,15S-Trihydroxy-6-keto-prosta-5E,13E-dien-1-oic-3,3,4,4-d4 acid; 6-Keto PGF1α-d4; Deuterated 6-keto PGF1α; 6-oxo-PGF1α-d4; (5Z,13E)-(9S,11R,15S)-9,11,15-Trihydroxy-6-oxoprosta-5,13-dien-1-oic-3,3,4,4-d4 acid
EINECS	Contact for details

Quality Control

Our 6-Keto Prostaglandin F1Alpha-D4 is manufactured under strict quality systems to ensure the high purity and isotopic enrichment required for analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity (by HPLC), isotopic purity (by MS), and chemical identity. We support compliance with GMP/GLP guidelines for research use.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere. This product is light-sensitive and easily oxidized; allow it to reach room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Isotopic Purity (by MS)	≥ 98.0 atom % D
Chemical Purity (Titration)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.