Description

D-Glucosamine, [6-3H] Hydrochloride is a tritium-labeled derivative of glucosamine hydrochloride, a fundamental amino sugar and a key building block for glycosaminoglycans. This radiolabeled compound is essential for high-sensitivity metabolic and pharmacokinetic tracer studies, enabling precise tracking of glucosamine uptake and incorporation in biological systems. It is a critical research tool for scientists in pharmaceutical development, biochemistry, and nutritional science investigating cartilage metabolism, osteoarthritis pathways, and glycoprotein synthesis.

Application

• Biochemical Tracer Studies: Used as a radiolabeled tracer to investigate the metabolic fate, pharmacokinetics, and biodistribution of glucosamine in vivo and in vitro.
• Cartilage & Osteoarthritis Research: Tracks the synthesis and turnover of proteoglycans and glycosaminoglycans (GAGs) in chondrocytes and cartilage tissue models.
• Glycoprotein & Glycolipid Biosynthesis: Studies the pathways of hexosamine biosynthesis and its incorporation into complex carbohydrates.
• Drug Discovery & Development: Facilitates the screening and mechanistic evaluation of novel therapeutics targeting joint health, inflammation, and metabolic disorders.
• Nutritional Science Research: Investigates the bioavailability, tissue distribution, and efficacy of glucosamine-containing nutraceuticals and supplements.
• Autoradiography & Imaging: Serves as a precursor for generating radiolabeled probes for histological and imaging techniques to visualize glucosamine localization.

Basic Information

Product Name	D-Glucosamine, [6-3H] Hydrochloride
CAS No.	82356-85-2
Molecular Formula	C6H14ClNO5 * (³H)
Molecular Weight	~215.6 g/mol (unlabeled)
Synonyms	6-Tritio-D-glucosamine Hydrochloride; [6-³H]-D-Glucosamine HCl; Tritiated D-Glucosamine Hydrochloride; (2R,3R,4R,5S)-3-Amino-6-³H-6-deoxy-2,4,5-trihydroxyhexanal Hydrochloride; 2-Amino-2-deoxy-6-³H-D-glucose Hydrochloride; Chitosamine-6-³H Hydrochloride; GlcN-6-³H HCl; D-Glucosamine-6-t Hydrochloride
EINECS	Contact for details

Quality Control

Every batch of our radiolabeled D-Glucosamine, [6-3H] Hydrochloride is produced and analyzed under strict quality systems to ensure high specific activity, radiochemical purity, and chemical stability. Comprehensive quality control includes verification of identity, specific activity (Ci/mmol or GBq/mmol), radiochemical purity (typically >97% by HPLC), and chemical purity. Certificates of Analysis (COA) detailing all analytical results, including solvent composition and radioactive concentration, are provided with each shipment to support compliant research.

Storage

Preserve in a tightly closed container, protected from light. Store frozen (-20°C or below) in the original solvent as specified on the label. This product is hygroscopic (moisture-sensitive). For long-term stability, it is recommended to store under inert atmosphere. Handle and dispose of in accordance with all applicable radiation safety regulations and guidelines.

Specification

Item	Specification
Appearance	Clear colorless to slightly yellow solution
Identification (HPLC, TLC)	Conforms to reference standard
Specific Activity	10-40 Ci/mmol (Contact for specific value)
Radiochemical Purity (HPLC)	≥ 97%
Chemical Purity (HPLC)	≥ 95%
Solvent	Ethanol:Water (Specified ratio, e.g., 9:1)
Radioactive Concentration	1 mCi/mL (Contact for specific value)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.