Description

10-Propargylaminopterin is a synthetic aminopterin derivative, a potent small molecule inhibitor of dihydrofolate reductase (DHFR). This compound matters for its targeted mechanism of action, offering a high degree of biochemical specificity for research and development applications. It is primarily needed by pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies engaged in anticancer drug discovery, enzyme inhibition studies, and biochemical pathway analysis.

Application

• Anticancer Research: Investigated as a potential chemotherapeutic agent due to its potent DHFR inhibition, which disrupts folate metabolism and DNA synthesis in rapidly dividing cells.
• Biochemical Research: Used as a specific tool compound in enzymatic assays to study the function and kinetics of dihydrofolate reductase.
• Drug Discovery & Development: Serves as a key intermediate or reference standard in the synthesis and screening of novel antifolate compounds.
• Academic Studies: Employed in university and institutional labs for fundamental research into folate metabolism, cell cycle regulation, and targeted therapy mechanisms.
• Pharmaceutical Reference Standard: Utilized as a high-purity analytical standard for quality control and method validation in pharmaceutical analysis.

Basic Information

Product Name	10-Propargylaminopterin
CAS No.	82318-25-0
Molecular Formula	C20H20N8O5
Molecular Weight	452.42 g/mol
Synonyms	10-Propargylaminopterin; 10-Propargyl-aminopterin; 4-Amino-10-propargylpteroic acid; NSC 781571; Propargylaminopterin; 10-(2-Propynyl)aminopterin; Antifolate DHFR inhibitor
EINECS	Contact for details

Quality Control

Our 10-Propargylaminopterin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity verification and identity confirmation by spectroscopic methods. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.