Description

D-Glucuronide Methyl Ester is a key monosaccharide derivative and a protected form of D-glucuronic acid, widely utilized as a versatile synthetic intermediate and biochemical research reagent. Its primary value lies in its role as a crucial building block for the synthesis of complex glycoconjugates, drug metabolites, and labeled compounds. This high-purity chemical is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical industries, particularly those focused on drug metabolism studies, prodrug development, and carbohydrate chemistry.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of glucuronidated drug metabolites for pharmacokinetic and ADME (Absorption, Distribution, Metabolism, and Excretion) studies.
• Biochemical Research: Used as a substrate or standard in enzymatic assays involving glucuronosyltransferases (UGTs) and for studying glucuronidation pathways.
• Glycoconjugate Synthesis: Serves as a protected glycosyl donor for the chemical and enzymatic synthesis of oligosaccharides, glycoproteins, and glycolipids.
• Prodrug Development: Employed in the design and synthesis of prodrugs that utilize glucuronide moieties for targeted drug delivery and activation.
• Analytical Standard: Functions as a high-purity reference standard in HPLC, LC-MS, and NMR for the identification and quantification of glucuronide compounds.
• Fine Chemical Synthesis: A valuable chiral starting material for the production of specialty chemicals and complex organic molecules.

Basic Information

Product Name	D-Glucuronide Methyl Ester
CAS No.	82228-14-6
Molecular Formula	C7H12O7
Molecular Weight	208.17 g/mol
Synonyms	Methyl D-glucopyranosiduronic acid; Methyl β-D-glucopyranosiduronic acid; Methyl β-D-glucuronide; Methyl D-glucuronoside; β-D-Glucopyranosiduronic acid methyl ester; (2S,3S,4S,5R,6S)-3,4,5-Trihydroxy-6-methoxyoxane-2-carboxylic acid
EINECS	Contact for details

Quality Control

Our D-Glucuronide Methyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity assessment and NMR/IR for structural confirmation, to ensure it meets the high standards required for research and synthesis. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment. We support compliance with relevant guidelines for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity. Ensure the storage area is well-ventilated and separate from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.