Description

Bz-Dmt-Deoxyadenosine 2-Clph Diester Barium) is a specialized, high-purity chemical intermediate primarily used in advanced oligonucleotide synthesis and pharmaceutical research. This compound matters for its role as a key building block in the production of modified nucleosides and nucleotides, enabling the development of novel therapeutic agents and diagnostic tools. It is essential for research institutions, pharmaceutical manufacturers, and biotechnology companies focused on antisense oligonucleotides, siRNA, and other nucleic acid-based technologies.

Application

• Oligonucleotide Synthesis: A critical phosphoramidite precursor for solid-phase synthesis of modified DNA/RNA strands.
• Pharmaceutical Research: Used in the development and scale-up of novel antisense, siRNA, and aptamer-based therapeutics.
• Diagnostic Probe Development: Serves as a modified base for creating high-specificity hybridization probes and primers.
• Bioconjugation: Facilitates the site-specific labeling of oligonucleotides with reporter molecules or functional groups.
• Academic & Contract Research: Employed in fundamental biochemical research exploring nucleic acid structure, function, and interactions.

Basic Information

Product Name	Bz-Dmt-Deoxyadenosine 2-Clph Diester Barium)
CAS No.	82224-95-1
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	5'-O-(4,4'-Dimethoxytrityl)-N6-benzoyl-2'-deoxyadenosine 3'-(2-chlorophenyl) phosphate barium salt; Bz-dA(Dmt) 2-ClPh Phosphotriester Barium Salt; N6-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyadenosine 3'-(2-chlorophenyl) phosphate barium complex; Bz-dA(Dmt)-2-ClPh Phosphotriester Barium; Barium 5'-O-DMT-N6-benzoyl-2'-deoxyadenosin-3'-yl 2-chlorophenyl phosphate
EINECS	Contact for details

Quality Control

Our Bz-Dmt-Deoxyadenosine 2-Clph Diester Barium) is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity, suitable for sensitive pharmaceutical applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable, and our quality assurance protocols are designed to meet the stringent requirements of oligonucleotide synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be handled under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Solubility	Soluble in anhydrous acetonitrile, DMF

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.