Description

m-Peg9-Tos CAS NO 82217-01-4 is a high-purity, monodisperse polyethylene glycol (PEG) derivative functionalized with a tosylate (p-toluenesulfonate) group at one terminus. This compound serves as a critical bifunctional linker and reactive intermediate, enabling the controlled introduction of hydrophilic PEG spacers into target molecules. It is essential for researchers and manufacturers in the pharmaceutical and bioconjugation sectors who require precise, reproducible, and high-yielding chemical modifications to enhance solubility, reduce immunogenicity, and improve the pharmacokinetic profiles of therapeutic agents.

Application

• Pharmaceutical PEGylation: A key reagent for the site-specific conjugation of peptides, proteins, oligonucleotides, and small molecule drugs to polyethylene glycol chains, improving their therapeutic properties.
• Bioconjugation & Probe Synthesis: Used to create PEGylated fluorescent dyes, imaging agents, and diagnostic probes for biomedical research and diagnostics.
• Polymer & Material Science: Acts as a versatile macro-initiator or monomer for synthesizing functionalized block copolymers, hydrogels, and surface coatings with tailored properties.
• Crosslinking Agent: Employed in the preparation of crosslinked networks for drug delivery systems and biocompatible matrices due to its reactive tosylate group.
• Intermediate for Further Functionalization: The tosylate group is an excellent leaving group, allowing for nucleophilic substitution to introduce amines, thiols, azides, or other functional groups, creating custom PEG linkers.

Basic Information

Product Name	m-Peg9-Tos
CAS No.	82217-01-4
Molecular Formula	C26H46O13S
Molecular Weight	598.70 g/mol
Synonyms	mPEG9-Tosylate; Monomethoxy Polyethylene Glycol 9 Tosylate; PEG9 Monomethyl Ether Tosylate; 2,5,8,11,14,17,20,23,26-Nonaoxaoctacosan-28-yl 4-methylbenzenesulfonate; mPEG9-OTs; Tos-PEG9-OMe; 4-Methylbenzenesulfonic acid 2,5,8,11,14,17,20,23,26-nonaoxaoctacos-28-yl ester
EINECS	Contact for details

Quality Control

Our m-Peg9-Tos is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and assay, NMR for structural confirmation, and mass spectrometry to ensure identity and monodispersity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications to support your research and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label or COA. Under these conditions, the product is stable for extended periods. Allow the container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Assay	≥ 90.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.