Description

11,12,15-Trihydroxyeicosatrienoic Acid is a specialized eicosanoid derivative, a key metabolite in the arachidonic acid cascade. This compound matters as a crucial biochemical standard and research tool for studying lipid signaling pathways, inflammation, and vascular biology. It is primarily needed by pharmaceutical R&D laboratories, academic research institutions, and manufacturers of high-purity biochemical reagents focused on metabolic and cardiovascular research.

Application

• Biochemical Research Standard: Used as a high-purity reference standard in analytical methods like HPLC and LC-MS for the quantification of eicosanoid metabolites in biological samples.
• Lipid Mediator Studies: Essential for investigating the biological activity and signaling pathways of trihydroxyeicosatrienoic acids (THETAs) in cellular models.
• Inflammation & Immunology Research: Applied in studies exploring the role of specific eicosanoids in inflammatory responses and immune system modulation.
• Cardiovascular Pharmacology: Serves as a tool compound for researching vascular tone, endothelial function, and related drug discovery targets.
• Enzyme Activity Assays: Utilized as a substrate or product in assays for enzymes like lipoxygenases and cytochrome P450s involved in eicosanoid biosynthesis.
• Diagnostic Kit Development: Employed in the development and calibration of diagnostic assays for specific lipid mediators.

Basic Information

Product Name	11,12,15-Trihydroxyeicosatrienoic Acid
CAS No.	82144-59-0
Molecular Formula	C₂₀H₃₂O₅
Molecular Weight	352.47 g/mol
Synonyms	11,12,15-THETA; 11,12,15-TriHETrE; (11S,12R,15S)-11,12,15-Trihydroxyicosa-5Z,8Z,13E-trienoic acid; 11,12,15-Trihydroxy-5Z,8Z,13E-eicosatrienoic acid; 11,12,15-Trihydroxy-5,8,13-eicosatrienoic acid; 11,12,15-TriHETE; 11,12,15-Trihydroxyeicosatrienoate
EINECS	Contact for details

Quality Control

Our 11,12,15-Trihydroxyeicosatrienoic Acid is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and chromatographic data is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. Due to its hygroscopic and light-sensitive nature, the product should be handled in a controlled environment and allowed to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Assay	≥ 97.0% (by titration)
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.