Description

N(Sub 1)-Phthalidyl-5-Fluorouracil is a key pharmaceutical intermediate and prodrug derivative of the antimetabolite 5-fluorouracil. This compound is valued for its role in enhancing drug delivery and targeting in advanced oncology treatments. It is primarily required by pharmaceutical R&D laboratories and manufacturers engaged in the synthesis of next-generation chemotherapeutic agents and targeted cancer therapies.

Application

• Pharmaceutical Intermediate: Critical building block in the synthesis of advanced chemotherapeutic prodrugs.
• Oncology Drug Development: Used in research and production of targeted cancer therapies to improve efficacy and reduce systemic toxicity.
• Prodrug Synthesis: Serves as a precursor for compounds designed for selective activation in tumor tissues.
• Biochemical Research: Employed in studies investigating nucleotide metabolism inhibition and anti-cancer mechanisms of action.
• API Manufacturing: Integral component in the controlled synthesis of active pharmaceutical ingredients (APIs) for oncology.

Basic Information

Product Name	N(Sub 1)-Phthalidyl-5-Fluorouracil
CAS No.	81820-68-0
Molecular Formula	C₁₃H₉FN₂O₄
Molecular Weight	276.22 g/mol
Synonyms	1-Phthalidyl 5-Fluorouracil; 5-FU Phthalidyl Ester; 5-Fluorouracil 1-Phthalidyl Derivative; N1-Phthalidyl-5-fluorouracil; FT-207 Analog; Tegafur Intermediate; 1-(2-Oxo-1,3-dioxoisoindolin-4-yl)-5-fluoropyrimidine-2,4(1H,3H)-dione
EINECS	Contact for details

Quality Control

Our N(Sub 1)-Phthalidyl-5-Fluorouracil is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical intermediate applications. Certificates of Analysis (COA) detailing all specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (typically 15-25°C). Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.