Description

Lolitrem A CAS NO 81771-20-2 is a potent indole-diterpene mycotoxin produced by specific endophytic fungi, primarily of the *Epichloë* genus. This compound is of critical importance in veterinary and agricultural research due to its role as the principal causative agent of ryegrass staggers, a neurological disorder affecting livestock. It is essential for researchers and quality control laboratories in the animal health, feed safety, and agricultural biotechnology sectors who require high-purity reference standards for toxicological studies, method development, and regulatory compliance testing.

Application

• Veterinary Toxicology Research: Used as a certified reference material (CRM) to study the pathogenesis and clinical effects of ryegrass staggers in ruminants.
• Feed and Forage Safety Analysis: Critical for developing and validating analytical methods (e.g., LC-MS/MS) to detect and quantify Lolitrem B and related mycotoxins in pasture grasses, hay, and silage.
• Agricultural Biotechnology: Employed in research aimed at developing endophyte-free or novel endophyte-infected grass cultivars to mitigate livestock toxicity.
• Pharmaceutical Research: Serves as a tool compound in neuroscience to investigate its mechanism of action on large-conductance calcium-activated potassium (BK) channels.
• Regulatory Compliance and Proficiency Testing: Used by commercial and government testing laboratories to ensure accuracy in monitoring programs and to meet food safety regulations.
• Chemical Synthesis & Derivative Studies: Acts as a complex molecular scaffold for the synthesis of analogues to explore structure-activity relationships.

Basic Information

Item	Detail
Product Name	Lolitrem A
CAS No.	81771-20-2
Molecular Formula	C₄₂H₅₅NO₇
Molecular Weight	685.90 g/mol
Synonyms	Lolitrem A; Lolitriol; 6,7-Epoxylolitrem B; 6β,7β-Epoxylolitrem B; (1R,2S,5S,7R,10R,11S,14S,15R,24S,27S,30S,33S,36S,37R)-36-[(2S)-2-Hydroxy-2-(4-hydroxy-3-methoxyphenyl)ethyl]-5,7,10,11,14,15,24,27,30,33,36,37-dodecahydro-2,15,27,30,33-pentamethyl-6,27-epoxy-8H-pyrido[2',1':10,11][1,4]dioxacyclooctadecino[2,3,4-gh]pyrrolo[2,1,5-de]quinolizine-8,18,21(7H,19H)-trione
EINECS	Contact for details

Quality Control

Our Lolitrem A is produced and handled under strict quality management protocols. Each batch undergoes comprehensive analytical characterization using techniques including HPLC, LC-MS, and NMR to confirm identity and purity. We provide a comprehensive Certificate of Analysis (COA) with each shipment, detailing batch-specific results. Our quality systems ensure traceability and consistency, meeting the stringent requirements of research and analytical reference standard applications.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below. Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation. The material should be stored in a cool, dry place dedicated for chemicals.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time matches CRM
Identification (MS)	Mass spectrum conforms to structure
Purity (HPLC)	≥ 95% (Area Percent)
Water Content (KF)	≤ 2.0 %
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.