Description

18-Hydroxycortisol is a significant steroid metabolite and a key intermediate in the synthesis of various corticosteroid hormones. This compound is essential for research and development in endocrinology and pharmaceutical manufacturing, where precise chemical intermediates are required. It is primarily utilized by pharmaceutical R&D laboratories, analytical reference standard producers, and manufacturers of active pharmaceutical ingredients (APIs) for metabolic studies and synthesis pathways.

Application

• Pharmaceutical Reference Standard: Used as a high-purity analytical standard for the quantification of cortisol metabolites in clinical and research laboratories.
• Biochemical Research: Critical intermediate in studies investigating steroidogenesis, adrenal gland function, and the biosynthesis pathways of corticosteroids.
• Active Pharmaceutical Ingredient (API) Synthesis: Serves as a key building block in the multi-step synthesis of more complex therapeutic steroid molecules.
• Diagnostic Kit Development: Employed in the development and calibration of immunoassays and LC-MS/MS kits for diagnosing endocrine disorders.
• Metabolite Profiling: Used in metabolomics research to understand steroid hormone metabolism and related disease states.

Basic Information

Product Name	18-Hydroxycortisol
CAS No.	81705-06-8
Molecular Formula	C21H30O6
Molecular Weight	378.46 g/mol
Synonyms	18-Hydroxycortisol; 11β,17α,21-Trihydroxy-18-oxopregn-4-ene-3,20-dione; 18-Oxocortisol; 18-Oxo-F; 18-Oxocortisol (11β,17α,21-Trihydroxy-18-oxopregn-4-ene-3,20-dione); 18-Hydroxycorticosterone metabolite
EINECS	Contact for details

Quality Control

Our 18-Hydroxycortisol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the stringent requirements for research and pharmaceutical applications. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.