Description

n-(2,4,6-Trinitrophenyl-6-n-Aminocaproyl)-1,2-Dipalmitoylphosphatidylethanolamine is a specialized, high-purity synthetic phospholipid derivative designed for advanced research and development applications. This compound is valued for its unique structure, which incorporates a trinitrophenyl (TNP) hapten conjugated to a dipalmitoyl phosphatidylethanolamine (DPPE) anchor via an aminocaproyl linker, making it a critical reagent in immunology and bioconjugation studies. It is primarily utilized by pharmaceutical R&D teams, diagnostic developers, and academic researchers working on vaccine adjuvants, liposomal drug delivery systems, and immunoassay development.

Application

• Liposome & Vaccine Adjuvant Research: As a functionalized phospholipid for constructing haptenated liposomes to study immune response mechanisms and adjuvant activity.
• Immunoassay Development: Used to create solid-phase coatings or tracer molecules in sensitive immunoassays, including ELISA, due to the TNP group's antigenic properties.
• Membrane Biology Studies: Incorporated into artificial lipid bilayers and model membranes to investigate protein-lipid interactions and membrane dynamics.
• Targeted Drug Delivery Systems: Serves as a key component in the design of ligand-targeted liposomal carriers for site-specific therapeutic delivery.
• Bioconjugation & Probe Synthesis: Acts as a versatile intermediate for coupling various biomolecules (e.g., peptides, antibodies) to lipid anchors.
• Immunology & Antibody Production: Employed as an immunogen or screening tool in the development and characterization of monoclonal and polyclonal antibodies.

Basic Information

Product Name	n-(2,4,6-Trinitrophenyl-6-n-Aminocaproyl)-1,2-Dipalmitoylphosphatidylethanolamine
CAS No.	81497-26-9
Molecular Formula	C58H104N4O17P
Molecular Weight	1160.43 g/mol
Synonyms	TNP-Aminocaproyl-DPPE; 1,2-Dipalmitoyl-sn-glycero-3-phosphoethanolamine-N-[6-[(2,4,6-trinitrophenyl)amino]hexanoyl]; N-(TNP-aminocaproyl)-DPPE; TNP-Cap-DPPE; Haptenated DPPE; TNP-Lipid Conjugate; (2,4,6-Trinitrophenyl)-6-aminocaproyl phosphatidylethanolamine
EINECS	Contact for details

Quality Control

Our n-(2,4,6-Trinitrophenyl-6-n-Aminocaproyl)-1,2-Dipalmitoylphosphatidylethanolamine is manufactured under strict quality protocols to ensure batch-to-batch consistency and high purity suitable for sensitive research applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and critical impurities. We adhere to cGMP principles for production and can provide material tailored to specific research-grade specifications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, keep containers sealed under an inert atmosphere (e.g., argon or nitrogen) to prevent degradation. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	Yellow to orange solid or film
Identification (HPLC/MS)	Conforms to structure
Identification (TLC)	Single major spot
Assay (HPLC)	≥ 95%
Solubility	Soluble in chloroform, methanol, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.