Description

Nipradilol CAS NO 81486-22-8 is a non-selective β-adrenergic receptor antagonist (β-blocker) with additional vasodilating properties. This dual pharmacological action makes it a compound of significant interest for research and development within the pharmaceutical sector. It is primarily utilized by researchers and manufacturers in the life sciences industry for investigating cardiovascular therapeutics and developing novel drug formulations.

Application

• Pharmaceutical Research & Development: Key intermediate or active pharmaceutical ingredient (API) in the synthesis of novel cardiovascular drugs.
• β-Blocker Studies: Used as a reference standard in pharmacological studies to investigate non-selective β-adrenergic receptor blockade.
• Vasodilation Mechanism Research: Employed in preclinical research to study compounds with combined β-blocking and vasodilatory effects for conditions like hypertension and glaucoma.
• Analytical Standard: Serves as a high-purity certified reference material (CRM) for quality control and analytical method development (e.g., HPLC, LC-MS).
• Biochemical Assays: Utilized in in-vitro assays to study receptor binding affinity and cellular signaling pathways.

Basic Information

Product Name	Nipradilol
CAS No.	81486-22-8
Molecular Formula	C19H27N3O4
Molecular Weight	361.44 g/mol
Synonyms	3,4-Dihydro-8-(2-hydroxy-3-isopropylaminopropoxy)-3-nitroxy-2H-1-benzopyran; K-351; Nipradilol Hydrochloride; Nipradiol; (±)-Nipradilol; 1(2H)-Benzopyran-3,4-diol, 8-[2-hydroxy-3-[(1-methylethyl)amino]propoxy]-3-nitrate, (±)-
EINECS	Contact for details

Quality Control

Our Nipradilol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, detailing specifications such as assay, related substances, and residual solvents. Our quality commitment aligns with cGMP standards for pharmaceutical intermediates and research chemicals.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. Keep container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.