Description

Dorzolamide Base is a high-purity, non-salt form of the potent carbonic anhydrase inhibitor, essential for advanced pharmaceutical synthesis. Its primary commercial value lies in serving as the critical active pharmaceutical ingredient (API) intermediate for manufacturing ophthalmic solutions targeting glaucoma and ocular hypertension. This compound is indispensable for pharmaceutical R&D laboratories, API manufacturers, and fine chemical suppliers requiring a reliable and well-characterized building block for drug development and production.

Application

• Primary Active Pharmaceutical Ingredient (API) Synthesis: Serves as the key intermediate in the commercial production of Dorzolamide Hydrochloride, the API used in anti-glaucoma medications.
• Ophthalmic Drug Formulation R&D: Used in research and development of novel topical solutions and suspensions for intraocular pressure management.
• Carbonic Anhydrase Inhibitor Studies: Employed as a reference standard in biochemical and pharmacological research to study enzyme inhibition mechanisms.
• Fine Chemical Intermediate: Utilized in the synthesis of more complex sulfonamide-based therapeutic agents and diagnostic tools.
• Analytical Reference Standard: Serves as a high-purity calibrant in quality control laboratories for HPLC, LC-MS, and other analytical methods.

Basic Information

Product Name	Dorzolamide Base
CAS No.	120279-90-5
Molecular Formula	C10H16N2O4S3
Molecular Weight	324.41 g/mol
Synonyms	(4S,6S)-4-(Ethylamino)-5,6-dihydro-6-methyl-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-Dioxide; L-671,152; MK-0507 Base; Trusopt Base; Dorzolamide (Free Base); 4H-Thieno[2,3-b]thiopyran-2-sulfonamide, 4-(ethylamino)-5,6-dihydro-6-methyl-, 7,7-dioxide, (4S,6S)-
EINECS	Contact for details

Quality Control

Our Dorzolamide Base is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for pharmaceutical applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to ICH guidelines for stability and impurity testing, ensuring the material meets the stringent requirements for API intermediate synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The container should be kept in a well-ventilated area and protected from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.5%
Related Substances (HPLC)	Total impurities ≤ 1.5% Any single unknown impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤ 20 ppm
Loss on Drying	≤ 0.5%
Specific Rotation	[α]20/D: Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.