Description

Rac-Cis Dorzolamide CAS NO 120279-37-0 is a synthetic carbonic anhydrase inhibitor, representing the racemic mixture of the cis-isomer of the active pharmaceutical ingredient. This compound is of significant interest in pharmaceutical research and development, particularly as a key intermediate or reference standard. It is primarily utilized by pharmaceutical manufacturers and research institutions engaged in the synthesis, analysis, and development of ophthalmic medications targeting glaucoma.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of the active enantiomer, Dorzolamide hydrochloride.
• Reference Standard: Used in analytical laboratories for method development, validation, and quality control testing of drug substances and products.
• Research & Development: Employed in preclinical and clinical studies to investigate carbonic anhydrase inhibition, pharmacokinetics, and metabolic pathways.
• Process Chemistry: Utilized for scaling up and optimizing synthetic routes in Active Pharmaceutical Ingredient (API) manufacturing.
• Impurity Profiling: Acts as a known impurity or related substance standard to ensure the purity and safety of the final drug product.

Basic Information

Product Name	Rac-Cis Dorzolamide
CAS No.	120279-37-0
Molecular Formula	C10H16N2O4S3
Molecular Weight	324.41 g/mol
Synonyms	(4S,6S)-4-(Ethylamino)-5,6-dihydro-6-methyl-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide (racemic cis-isomer); (±)-cis-4-Ethylamino-5,6-dihydro-6-methyl-4H-thieno[2,3-b]thiopyran-2-sulfonamide-7,7-dioxide; L-671,152; Dorzolamide Racemic cis-Isomer; Trusopt Intermediate; Carbonic Anhydrase II Inhibitor (racemic)
EINECS	Contact for details

Quality Control

Our Rac-Cis Dorzolamide is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide full traceability and support regulatory filings. Certificates of Analysis (COA) detailing specifications such as assay, enantiomeric purity, and impurity profiles are available upon request, supporting compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which may affect stability and handling properties. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.0%
Purity (HPLC, Area %)	≥99.0%
Related Substances (HPLC)	Individual impurity: ≤0.5%; Total impurities: ≤1.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.