Description

4R,6R-Dorzolamide is a potent and selective carbonic anhydrase inhibitor, specifically the (4R,6R)-enantiomer of dorzolamide. This high-purity chiral intermediate is critical for the synthesis of advanced active pharmaceutical ingredients (APIs) targeting ophthalmic conditions. It is primarily required by pharmaceutical manufacturers and advanced research institutions engaged in developing and producing next-generation glaucoma treatments and other carbonic anhydrase-mediated therapeutics.

Application

• Primary Active Pharmaceutical Ingredient (API) Synthesis: Key chiral building block for the manufacture of ophthalmic drugs.
• Glaucoma Treatment R&D: Essential for research into novel topical carbonic anhydrase inhibitors for intraocular pressure reduction.
• Chiral Reference Standard: Serves as a high-purity standard for analytical method development and quality control in pharmaceutical labs.
• Process Chemistry & Scale-Up: Used in optimizing synthetic routes and scaling up production of dorzolamide-based APIs.
• Biochemical Research: Tool compound for studying the structure-activity relationship (SAR) and inhibition mechanisms of carbonic anhydrase isoforms.

Basic Information

Product Name	4R,6R-Dorzolamide
CAS No.	120279-95-0
Molecular Formula	C10H16N2O4S3
Molecular Weight	324.40 g/mol
Synonyms	(4R,6R)-4-(Ethylamino)-5,6-dihydro-6-methyl-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide; (4R,6R)-Dorzolamide; L-671,152; Dorzolamide (4R,6R)-Isomer; Trusopt Intermediate; (-)-Dorzolamide; (4R-trans)-4-(Ethylamino)-5,6-dihydro-6-methyl-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide
EINECS	Contact for details

Quality Control

Our 4R,6R-Dorzolamide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets exacting standards for pharmaceutical intermediate applications. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.5%
Chiral Purity (Enantiomeric Excess)	≥99.0%
Related Substances (HPLC)	Total impurities ≤1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.