Description

Pilocarpine Nitrate is a high-purity pharmaceutical-grade salt of the parasympathomimetic alkaloid pilocarpine. This compound is critical for its potent muscarinic receptor agonist activity, making it a key active pharmaceutical ingredient (API) in ophthalmic solutions. It is primarily sought by manufacturers in the pharmaceutical and life sciences sectors for the formulation of medications used to treat conditions such as glaucoma and ocular hypertension, as well as for research applications in neuropharmacology.

Application

• Ophthalmic Drug Manufacturing: Primary active ingredient in prescription eye drops for reducing intraocular pressure in glaucoma and ocular hypertension patients.
• Pharmaceutical Research: Used as a reference standard and tool compound in studies of cholinergic systems, salivary secretion, and smooth muscle contraction.
• Diagnostic Agent: Employed in sweat tests (e.g., for cystic fibrosis diagnosis) due to its action on sweat glands.
• Veterinary Medicine: Formulated in treatments for certain ocular conditions in animals.
• API Synthesis: Serves as a starting material or intermediate in the synthesis of more complex cholinergic agents.

Basic Information

Product Name	Pilocarpine Nitrate
CAS No.	148-72-1
Molecular Formula	C11H16N2O2 • HNO3
Molecular Weight	271.27 g/mol
Synonyms	Pilocarpine Mononitrate; (3S,4R)-3-Ethyl-4-[(1-methyl-1H-imidazol-5-yl)methyl]dihydrofuran-2(3H)-one nitrate; Pilocarpus Nitrate; Ocusert Pilo (trade name related); Isopto Carpine (trade name related); Pilagan Nitrate; Pilokarpin nitrat
EINECS	205-736-1

Quality Control

Our Pilocarpine Nitrate is manufactured and tested to meet stringent pharmacopeial standards, including USP and EP monographs. Every batch undergoes comprehensive analytical testing for identity, potency, and purity. A detailed Certificate of Analysis (COA) is provided, confirming compliance with specifications for assay, related substances, residual solvents, and microbiological quality. Our quality management system is designed to ensure traceability and consistency for GMP-driven applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. For long-term stability, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White or almost white, crystalline powder
Identification (IR)	Conforms to standard
Identification (Nitrate)	Conforms to standard
Assay (HPLC)	98.0% - 102.0% (on dried basis)
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any individual impurity ≤ 0.5%
Heavy Metals	≤ 20 ppm
Microbial Limits	Meets USP <61> and <62> requirements

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.