Description

Dorzolamide Hydrochloride CAS NO 120279-36-9 is a potent and selective carbonic anhydrase inhibitor, primarily used as an active pharmaceutical ingredient (API). Its primary commercial value lies in its critical role in the formulation of ophthalmic solutions for the treatment of elevated intraocular pressure, such as in glaucoma. This high-purity compound is essential for pharmaceutical manufacturers, research institutions, and developers of advanced therapeutic systems requiring a reliable and well-characterized API.

Application

• Ophthalmic Pharmaceutical Formulations: Primary use as the active ingredient in eye drop solutions for managing glaucoma and ocular hypertension.
• Drug Substance Manufacturing: Serves as the key bulk API for the production of finished dosage forms under Good Manufacturing Practice (GMP) conditions.
• Pharmaceutical Research & Development (R&D): Used in preclinical and clinical studies for investigating new therapeutic applications or combination therapies.
• Analytical Reference Standard: Employed as a high-purity standard in quality control laboratories for HPLC, titration, and spectroscopic assays.
• Biochemical Research: Utilized in enzymatic studies to investigate carbonic anhydrase inhibition mechanisms and kinetics.

Basic Information

Product Name	Dorzolamide Hydrochloride
CAS No.	120279-36-9
Molecular Formula	C10H17ClN2O4S3•HCl
Molecular Weight	408.96 g/mol
Synonyms	(4S,6S)-4-(Ethylamino)-5,6-dihydro-6-methyl-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide hydrochloride; L-671,152; MK-0507; Trusopt (Brand Name); Dorzolamide HCl; Dorzolamide Hydrochloride; Dorzolamide Monohydrochloride
EINECS	Contact for details

Quality Control

Our Dorzolamide Hydrochloride is manufactured and tested to meet stringent pharmaceutical-grade standards. Quality assurance protocols are designed to ensure identity, purity, strength, and composition, aligning with ICH guidelines. A comprehensive Certificate of Analysis (COA) is provided with each batch, detailing results from tests including identification, assay, related substances, residual solvents, and specific tests. We support compliance with major pharmacopoeial standards (USP, EP, BP) upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. The container should be kept tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to almost white crystalline powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Related Substances (HPLC)	Total impurities: NMT 1.0% Any individual impurity: NMT 0.5%
Water Content (KF)	NMT 1.0%
Residue on Ignition	NMT 0.1%
Heavy Metals	NMT 20 ppm
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.