Description

Naphazoline Nitrate CAS NO 5144-52-5 is a white to off-white crystalline powder belonging to the class of imidazoline derivatives. It is a critical active pharmaceutical ingredient (API) valued for its potent vasoconstrictive properties. This compound is primarily required by pharmaceutical manufacturers for the formulation of ophthalmic and nasal decongestant solutions.

Application

• Ophthalmic Solutions: As the key active ingredient in eye drops for the temporary relief of redness, irritation, and dryness caused by minor eye conditions.
• Nasal Decongestants: Used in nasal sprays and drops to provide rapid relief from nasal congestion associated with allergies, colds, or sinusitis.
• Pharmaceutical Intermediates: Serves as a crucial building block in the synthesis of more complex pharmaceutical compounds within its therapeutic class.
• Veterinary Medicines: Incorporated into topical formulations for animals to address conjunctival and nasal congestion.
• Research & Development: Utilized in pharmacological studies and clinical research focusing on adrenergic receptors and vasoconstriction mechanisms.
• Compounding Pharmacy: Used by licensed compounding pharmacists to prepare customized medication formulations as per specific patient prescriptions.

Basic Information

Product Name	Naphazoline Nitrate
CAS No.	5144-52-5
Molecular Formula	C14H14N2 • HNO3
Molecular Weight	273.28 g/mol
Synonyms	2-(1-Naphthylmethyl)-2-imidazoline mononitrate; Naphazoline Mononitrate; Naphcon; Privine Nitrate; Albalon; Vasocon; 2-(Naphthalen-1-ylmethyl)-4,5-dihydro-1H-imidazole nitrate; Naphthazoline Nitrate
EINECS	225-913-8

Quality Control

Our Naphazoline Nitrate is manufactured under strict quality management systems. It undergoes rigorous analytical testing to ensure it meets high-purity standards suitable for pharmaceutical applications, including compliance with relevant pharmacopoeial monographs (e.g., USP, EP). A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each batch to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which can affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to standard
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0% Any individual impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.