Description

Dorzolamide Hydrochloride CAS NO 130693-82-2 is a potent and selective carbonic anhydrase inhibitor, primarily used as an active pharmaceutical ingredient (API). Its primary commercial value lies in the formulation of ophthalmic solutions for the effective management of elevated intraocular pressure, a key factor in conditions like glaucoma. This high-purity compound is essential for pharmaceutical manufacturers and research institutions developing next-generation ophthalmic treatments and conducting related biochemical studies.

Application

• Ophthalmic Drug Manufacturing: Primary use as the active pharmaceutical ingredient (API) in topical eye drop solutions for glaucoma and ocular hypertension.
• Pharmaceutical R&D: Serves as a critical reference standard and starting material in the research and development of new carbonic anhydrase inhibitors.
• Combination Therapy Formulations: Used in fixed-dose combination products with other intraocular pressure-lowering agents like timolol.
• Biochemical Research: Employed in enzymatic studies to investigate the mechanism and kinetics of carbonic anhydrase isoenzymes.
• Analytical Standard: Utilized as a high-purity standard for quality control (QC) and analytical method development in pharmaceutical laboratories.

Basic Information

Product Name	Dorzolamide Hydrochloride
CAS No.	130693-82-2
Molecular Formula	C10H17ClN2O4S3•HCl
Molecular Weight	360.70 g/mol (as hydrochloride)
Synonyms	(4S,6S)-4-(Ethylamino)-5,6-dihydro-6-methyl-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide hydrochloride; L-671,152 hydrochloride; MK-507 hydrochloride; Trusopt (brand name API); Dorzolamide HCl; Dorzolamide monohydrochloride
EINECS	Contact for details

Quality Control

Our Dorzolamide Hydrochloride is manufactured under strict quality management systems, targeting specifications suitable for pharmaceutical applications. Each batch is subjected to comprehensive analytical testing, including identification, assay, impurity profiling, and residual solvent analysis, to ensure compliance with in-house and relevant pharmacopeial standards. A Certificate of Analysis (COA) documenting purity, related substances, and other critical parameters is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Related Substances (HPLC)	Individual impurity: NMT 0.5% Total impurities: NMT 2.0%
Water Content (KF)	NMT 1.0%
Residue on Ignition	NMT 0.1%
Heavy Metals	NMT 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.