Description

Dorzolamide Hydrochloride CAS NO 122028-16-4 is a potent and selective carbonic anhydrase inhibitor used as an active pharmaceutical ingredient (API). It is a critical component in the formulation of ophthalmic solutions for the effective management of elevated intraocular pressure, a primary risk factor for glaucoma. This high-purity compound is essential for pharmaceutical manufacturers, research institutions, and developers of advanced ophthalmic drug delivery systems.

Application

• Primary Active Pharmaceutical Ingredient (API) in topical ophthalmic solutions for glaucoma and ocular hypertension.
• Key intermediate in the synthesis of novel carbonic anhydrase inhibitor derivatives for research and development.
• Reference standard for analytical method development and quality control in pharmaceutical laboratories.
• Component in combination drug therapies for enhanced efficacy in intraocular pressure reduction.
• Material for preclinical and clinical studies investigating new ophthalmic formulations.
• Raw material for the production of generic ophthalmic medications.

Basic Information

Product Name	Dorzolamide Hydrochloride
CAS No.	122028-16-4
Molecular Formula	C10H17ClN2O4S3 • HCl
Molecular Weight	408.96 g/mol
Synonyms	(4S,6S)-4-(Ethylamino)-5,6-dihydro-6-methyl-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide hydrochloride; L-671,152 hydrochloride; MK-0507 hydrochloride; Trusopt (brand name API); Dorzolamide HCl; Dorzolamide monohydrochloride
EINECS	Contact for details

Quality Control

Our Dorzolamide Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets stringent specifications for pharmaceutical use, including identity, purity, and impurity profiles. A Certificate of Analysis (COA) is provided with every shipment, detailing results for assay, related substances, residual solvents, and other critical parameters. We support compliance with ICH guidelines, and our quality systems are designed to meet the requirements of global regulatory bodies.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C limits
Heavy Metals	≤ 20 ppm
Sulfated Ash	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.