Description

Oleic Acid n-Hydroxysuccinimide Ester is a high-purity, activated ester derivative of oleic acid, designed for efficient bioconjugation and labeling applications. This compound is critical for researchers and manufacturers requiring a reliable, reactive linker to introduce hydrophobic oleoyl chains onto amine-containing molecules like proteins, peptides, or amino-modified surfaces. It is an essential reagent for professionals in pharmaceutical development, diagnostic assay manufacturing, and advanced materials science who need to modify biomolecules for enhanced stability, targeting, or detection.

Application

• Bioconjugation & Protein Labeling: Primary reagent for covalently attaching oleic acid (C18:1) chains to antibodies, enzymes, or other proteins to alter hydrophobicity, improve membrane association, or create immunogens.
• Lipid Nanoparticle (LNP) & Drug Delivery System Development: Used to functionalize lipid components or surface-modify nanocarriers for targeted drug delivery, particularly in mRNA and siRNA therapeutic formulations.
• Diagnostic Reagent Synthesis: Key intermediate in producing labeled antigens, haptens, or probes for immunoassays (ELISA, lateral flow tests) and biosensors.
• Surface Modification & Biomaterials: Employed to create hydrophobic coatings or to conjugate bioactive molecules onto amine-functionalized polymers, beads, or sensor chips.
• Crosslinking Agent: Serves as a homobifunctional crosslinker for amine-amine coupling in the study of protein-protein interactions or material crosslinking.
• Research & Development: Fundamental tool in biochemical research for studying lipid-protein interactions, cell membrane dynamics, and signal transduction pathways.

Basic Information

Product Name	Oleic Acid n-Hydroxysuccinimide Ester
CAS No.	81480-40-2
Molecular Formula	C22H37NO4
Molecular Weight	379.54 g/mol
Synonyms	N-Hydroxysuccinimide Oleate; Oleic Acid N-Hydroxysuccinimide Ester; Oleic Acid NHS Ester; (Z)-Octadec-9-enoic Acid 2,5-Dioxopyrrolidin-1-yl Ester; N-Succinimidyl Oleate; 1-[(9Z)-9-Octadecenoyloxy]-2,5-pyrrolidinedione; Oleoyl N-Hydroxysuccinimide Ester; Oleic Acid Active Ester
EINECS	Contact for details

Quality Control

Our Oleic Acid n-Hydroxysuccinimide Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistent performance for sensitive bioconjugation workflows. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment. We support compliance with relevant GMP and ISO 9001 standards for research and production use.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to prevent hydrolysis. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or waxy solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Purity (HPLC, Area%)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMF, DMSO, acetonitrile, dichloromethane

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.