Description

1,2-Dihexadecanoyl-Sn-Glycero-3-Phospho-[n-Dansyl]Ethanolamine is a high-purity, synthetic phospholipid derivative featuring a covalently attached dansyl fluorophore. This compound is critically important as a fluorescent membrane probe for studying lipid bilayer dynamics, membrane fusion, and cellular trafficking processes. It is an essential tool for researchers and developers in biophysics, pharmaceutical R&D, and advanced diagnostics, enabling precise, real-time visualization of membrane interactions.

Application

• Fluorescent Labeling in Membrane Biophysics: As a key component in model membrane systems (liposomes, supported lipid bilayers) to study lipid diffusion, phase separation, and domain formation via fluorescence spectroscopy and microscopy.
• Cell Biology & Trafficking Studies: Used to trace endocytosis, exocytosis, and intracellular vesicle movement by incorporating the probe into cellular membranes.
• Drug Delivery Research: Employed in the development and characterization of lipid-based nanoparticle (LNP) delivery systems to monitor stability, cellular uptake, and payload release kinetics.
• Diagnostic Assay Development: Serves as a critical reagent in fluorescence-based assays for detecting phospholipases, lipid transfer proteins, or other membrane-interacting enzymes.
• Sensor Technology: Utilized in the fabrication of biosensors where membrane integrity or specific binding events need to be reported via a fluorescence signal.
• Academic & Industrial R&D: A fundamental research chemical for universities, government labs, and biotech companies investigating membrane structure and function.

Basic Information

Product Name	1,2-Dihexadecanoyl-Sn-Glycero-3-Phospho-[n-Dansyl]Ethanolamine
CAS No.	81425-71-0
Molecular Formula	C55H95N2O11P
Molecular Weight	991.39 g/mol
Synonyms	Dansyl-DHPE; N-(5-Dimethylaminonaphthalene-1-sulfonyl)-1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine; 1,2-Dipalmitoyl-sn-glycero-3-phosphoethanolamine-N-(5-dimethylaminonaphthalene-1-sulfonyl); DPPE-Dansyl; Fluorescent DPPE; N-Dansyl-1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine; L-α-Phosphatidylethanolamine-N-dansyl (dipalmitoyl); Dansyl Phosphatidylethanolamine
EINECS	Contact for details

Quality Control

Every batch of our 1,2-Dihexadecanoyl-Sn-Glycero-3-Phospho-[n-Dansyl]Ethanolamine is manufactured under strict quality systems and undergoes comprehensive analytical characterization. We guarantee high chemical and isomeric purity suitable for sensitive research applications. A detailed Certificate of Analysis (COA) providing HPLC purity, structural confirmation (NMR/MS), and fluorescence properties is supplied with each shipment to ensure traceability and compliance with your research protocols.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. Under these conditions, the product is stable for years. Allow the vial to warm to room temperature before opening to minimize condensation and moisture uptake.

Specification

Item	Specification
Appearance	Yellow to orange solid or film
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 98% (Area %)
Solubility	Chloroform, Methanol, Ethanol
Fluorescence Properties	Excitation ~340 nm, Emission ~520 nm (solvent dependent)
Residual Solvents	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.