Description

N,n-Diethylethanamine-5'-o-Thiophosphonoadenosine(1:1) is a specialized, high-purity chemical adduct of significant interest in advanced pharmaceutical and biochemical research. This compound matters as a critical reagent and synthetic intermediate for the development of nucleotide analogs and prodrugs, enabling targeted therapeutic applications. It is primarily needed by research institutions, pharmaceutical R&D laboratories, and fine chemical manufacturers focused on antiviral, anticancer, and metabolic disorder research programs. The product is supplied with a guaranteed Certificate of Analysis to ensure batch-to-batch consistency for sensitive applications.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel nucleotide-based prodrugs and active pharmaceutical ingredients (APIs).
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies, particularly those involving kinases and phosphotransferases.
• Antiviral Drug Development: Serves as a precursor for nucleoside phosphoramidate and thiophosphate analogs under investigation for antiviral therapies.
• Prodrug Synthesis: Employed in the design of prodrugs to improve the bioavailability and cellular uptake of nucleotide analogs.
• Labeling and Tracing Studies: Potential use in the preparation of radiolabeled or tagged compounds for metabolic pathway analysis.
• Fine Chemical Synthesis: Valuable reagent for custom synthesis and contract manufacturing of complex, high-value specialty chemicals.

Basic Information

Product Name	N,n-Diethylethanamine-5'-o-Thiophosphonoadenosine(1:1)
CAS No.	81415-28-3
Molecular Formula	C₁₇H₃₁N₈O₃PS
Molecular Weight	482.53 g/mol
Synonyms	Adenosine, 5'-[P-(diethylamino)thiophosphonate], triethylamine salt; 5'-O-[P-(Diethylamino)thiophosphoryl]adenosine triethylamine salt; GS-7340 intermediate; Tenofovir alafenamide intermediate; Phosphoramidate prodrug intermediate; Nucleoside phosphoramidate; Adenosine thiophosphoramidate; BMS-986001 analog intermediate
EINECS	Contact for details

Quality Control

Every batch of N,n-Diethylethanamine-5'-o-Thiophosphonoadenosine(1:1) is manufactured under strict quality management systems. Our products undergo rigorous quality testing to ensure compliance with industry standards for research and pharmaceutical use. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with each shipment to guarantee reliable and reproducible performance in your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. For long-term storage, consider storing desiccated at -20°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.