Description

E-Maleimidocapronic Acid Hydrazide is a heterobifunctional crosslinking reagent featuring a maleimide group and a hydrazide group. This compound is essential for creating stable, site-specific conjugates between biomolecules, such as antibodies and enzymes, and various probes or surfaces. It is a critical tool for researchers and manufacturers in the fields of bioconjugation, diagnostic assay development, and targeted drug delivery systems.

Application

• Antibody-Drug Conjugate (ADC) Linker: Site-specific conjugation of cytotoxic drugs to monoclonal antibodies via the hydrazide moiety.
• Protein/Peptide Labeling: Covalent attachment of fluorescent dyes, enzymes, or other reporter molecules to proteins for imaging and detection.
• Surface Immobilization: Functionalization of biosensor chips, microarrays, or nanoparticles with biomolecules for diagnostic applications.
• Crosslinking Agent: For studying protein-protein interactions or creating stable protein complexes.
• Biomaterial Modification: Incorporation into hydrogels or polymer scaffolds to covalently bind bioactive peptides or growth factors.
• Diagnostic Reagent Synthesis: Production of enzyme-labeled antibodies or antigens for ELISA and lateral flow assays.

Basic Information

Product Name	E-Maleimidocapronic Acid Hydrazide
CAS No.	81186-33-6
Molecular Formula	C15H21N3O5
Molecular Weight	323.35 g/mol
Synonyms	EMCH; 6-Maleimidocaproic acid hydrazide; Maleimidocaproyl hydrazide; N-(ε-Maleimidocaproic acid) hydrazide; N-(6-Maleimidocaproyl)hydrazine; 6-(Maleimido)hexanoic acid hydrazide; 6-Maleimidohexanoic hydrazide; 1-(6-Maleimidocaproyl)hydrazine
EINECS	Contact for details

Quality Control

Our E-Maleimidocapronic Acid Hydrazide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for sensitive bioconjugation applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMF, DMSO; Slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.