Description

Adenylyl (2'-5')-Adenylyl-(2'-5')Adenosine Bis-Phosphoramidate is a chemically defined, high-purity nucleotide analog of significant research interest. This compound is valued for its role as a stable analog of 2'-5' oligoadenylate (2-5A), a key mediator in the interferon-induced antiviral response pathway. It is primarily utilized by researchers in biochemistry, molecular biology, and virology for studying RNA degradation mechanisms, enzyme kinetics, and innate immune signaling.

Application

• Biochemical Research: Used as a substrate or inhibitor in studies of 2'-5'-oligoadenylate synthetase (OAS) and RNase L enzyme activity.
• Antiviral Mechanism Studies: Serves as a stable analog to investigate the 2-5A pathway's role in cellular defense against viral infections.
• Enzyme Kinetics: Employed in assays to determine kinetic parameters and inhibition constants for nucleotidyltransferases and phosphodiesterases.
• Signal Transduction Research: A tool compound for probing interferon-mediated signaling cascades and innate immune responses.
• Pharmaceutical Development: Potential starting material or reference standard in the discovery of novel immunomodulatory or antiviral agents.
• Diagnostic Reagent Development: Can be used in the development of enzymatic assays or detection systems related to interferon activity.

Basic Information

Product Name	Adenylyl (2'-5')-Adenylyl-(2'-5')Adenosine Bis-Phosphoramidate
CAS No.	81010-22-2
Molecular Formula	C30H39N15O19P3
Molecular Weight	998.64 g/mol
Synonyms	2'-5' ppp(A2'p)nA; 2-5A Triphosphate Core; P1,P3-Bis(5'-adenosyl) Triphosphate; 2',5'-Oligoadenylate Analog; 2-5A Bis-Phosphoramidate; Adenosine-2',5'-triphosphoadenosine; A(2'p5')A(2'p5')A bisphosphoramidate; 5'-O-[(Phosphonoamino)phosphonyl]adenylyl-(2'->5')-adenylyl-(2'->5')adenosine
EINECS	Contact for details

Quality Control

Our nucleotide analogs are produced under strict quality control protocols to ensure batch-to-batch consistency and high purity for research applications. Each lot is characterized using advanced analytical techniques including HPLC, MS, and NMR. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your research documentation and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.