Description

3-(p-Tolylsulfonylamino)-5-Fluorouracil is a specialized fluorinated uracil derivative, a key intermediate in advanced pharmaceutical synthesis. This compound matters for its role in developing novel therapeutic agents, particularly in oncology research and targeted drug delivery systems. It is primarily needed by pharmaceutical R&D laboratories, fine chemical manufacturers, and academic institutions engaged in nucleoside chemistry and anticancer drug discovery.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of novel fluoropyrimidine-based anticancer and antiviral agents.
• Oncology Research: Used in the development and study of prodrugs and targeted therapies designed to inhibit tumor cell proliferation.
• Nucleoside Chemistry: Serves as a modified uracil precursor for creating fluorinated nucleoside analogs with enhanced biological activity.
• Biochemical Research: Employed as a tool compound to study enzyme inhibition, particularly thymidylate synthase, and DNA/RNA metabolism.
• Fine Chemical Synthesis: Utilized in multi-step organic synthesis for introducing the fluorouracil-tosylamino pharmacophore into complex molecules.

Basic Information

Product Name	3-(p-Tolylsulfonylamino)-5-Fluorouracil
CAS No.	80812-32-4
Molecular Formula	C12H12FN3O4S
Molecular Weight	313.31 g/mol
Synonyms	5-Fluoro-3-[(4-methylphenyl)sulfonylamino]-2,4(1H,3H)-pyrimidinedione; 3-[(p-Tolylsulfonyl)amino]-5-fluorouracil; 3-(Tosylamino)-5-fluorouracil; 5-Fluoro-3-(tosylamino)uracil; 3-Tosylamino-5-fluorouracil; 5-FU Tosyl Derivative; N-(p-Tolylsulfonyl)-5-fluorouracil-3-amine
EINECS	Contact for details

Quality Control

Our 3-(p-Tolylsulfonylamino)-5-Fluorouracil is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the stringent requirements for pharmaceutical intermediates. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from incompatible materials. The product is light-sensitive and should be stored away from light.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.