Description

5'-o-(L-Valyl)-5-Fluorouridine Hcl is a chemically modified nucleoside derivative, specifically a valine ester prodrug of the active metabolite 5-fluorouridine. This compound is of significant interest in pharmaceutical research and development due to its potential as a precursor to enhance the bioavailability and targeted delivery of fluoropyrimidine-based therapeutics. It is primarily utilized by research scientists and process development chemists in the pharmaceutical and biotechnology industries for the synthesis of novel anticancer agents and antiviral prodrugs.

Application

• Pharmaceutical Intermediate: A key building block in the research and synthesis of novel nucleoside analog prodrugs for oncology applications.
• Anticancer Agent Research: Serves as a precursor in studies targeting improved therapeutic profiles of 5-fluorouracil derivatives, aiming for enhanced tumor selectivity and reduced systemic toxicity.
• Antiviral Drug Development: Investigated as a potential intermediate for prodrug strategies in the development of antiviral medications.
• Biochemical Research: Used as a specialized reagent in studies of nucleoside metabolism, enzyme inhibition, and mechanism of action.
• Process Chemistry & Scale-up: Employed in process development and optimization for the commercial manufacturing of advanced active pharmaceutical ingredients (APIs).
• Reference Standard: Can be supplied as a high-purity compound for use as an analytical reference standard in quality control (QC) and research laboratories.

Basic Information

Product Name	5'-o-(L-Valyl)-5-Fluorouridine Hcl
CAS No.	80667-13-6
Molecular Formula	C15H21FN3O7 • HCl
Molecular Weight	419.81 g/mol (Free base: 383.35 g/mol)
Synonyms	5'-O-L-Valyl-5-fluorouridine hydrochloride; 5-Fluorouridine 5'-(L-valinate) hydrochloride; 5-FUrd-Val HCl; 1-((2R,3R,4R,5R)-3,4-Dihydroxy-5-((((S)-1-hydroxy-3-methyl-1-oxobutan-2-yl)amino)methyl)tetrahydrofuran-2-yl)-5-fluoropyrimidine-2,4(1H,3H)-dione hydrochloride; Valine-5-fluorouridine ester HCl; 5-Fluorouridine valyl ester hydrochloride
EINECS	Contact for details

Quality Control

Every batch of 5'-o-(L-Valyl)-5-Fluorouridine Hcl is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the identity, purity, and consistency required for critical research and development applications. A detailed Certificate of Analysis (COA) specifying results for assay, purity (HPLC), related substances, residual solvents, and other critical parameters is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Purity (HPLC)	≥ 98.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.