Description

Suc-Phe-Leu-Phe-Sbzl is a synthetic peptide derivative, specifically a succinylated tetrapeptide chloromethyl ketone, widely recognized for its role as a potent and selective inhibitor of chymotrypsin-like serine proteases. Its primary value lies in its utility as a critical biochemical tool for studying protease activity, enzyme kinetics, and cellular signaling pathways. This compound is essential for researchers and developers in pharmaceutical R&D, proteomics, and biochemical assay development, where precise enzyme inhibition is required.

Application

• Biochemical Research: As a standard inhibitor for chymotrypsin, cathepsin G, and related serine proteases in enzymatic studies.
• Pharmaceutical Development: Used in target validation and screening assays for drug discovery programs focused on inflammatory diseases and immune disorders.
• Proteomics: Employed as an affinity ligand or activity-based probe to isolate and characterize specific protease families from complex biological samples.
• Diagnostic Reagent Manufacturing: A key component in the formulation of specialized diagnostic kits for measuring protease activity in clinical samples.
• Cell Biology Studies: Used to investigate the role of specific proteases in cellular processes such as apoptosis, migration, and protein processing.

Basic Information

Product Name	Suc-Phe-Leu-Phe-Sbzl
CAS No.	80651-94-1
Molecular Formula	C35H48N4O7S
Molecular Weight	668.85 g/mol
Synonyms	Succinyl-Phenylalanyl-Leucyl-Phenylalanyl Chloromethyl Ketone; Suc-F-L-F-CMK; Suc-Phe-Leu-Phe-CH2Cl; Chymotrypsin Inhibitor I; N-Succinyl-L-phenylalanyl-L-leucyl-L-phenylalanyl chloromethyl ketone; Protease Inhibitor Suc-F-L-F-CMK; Benzyloxycarbonyl-Leucyl-Phenylalanyl Chloromethyl Ketone derivative
EINECS	Contact for details

Quality Control

Our Suc-Phe-Leu-Phe-Sbzl is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity verification, mass spectrometry (MS) for identity confirmation, and NMR for structural validation. We provide Certificates of Analysis (COA) detailing all specifications to ensure traceability and compliance with research-grade standards. Our quality commitment supports reliable and reproducible results in your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a desiccator before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with molecular ion [M+H]+
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.