Description

10,10-Dimethyl-10-Deazaaminopterin is a synthetic analog of folic acid, belonging to the class of antimetabolites. This compound is of significant interest for its role as a potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folate metabolism and nucleotide synthesis. It is primarily utilized by research institutions and pharmaceutical developers engaged in oncology research, biochemistry, and the development of novel therapeutic agents. Its structural modification offers a valuable tool for studying enzyme kinetics and resistance mechanisms.

Application

• Biochemical Research: As a high-purity reference standard and inhibitor in enzymatic studies of dihydrofolate reductase (DHFR).
• Oncology Research: Investigation of antiproliferative mechanisms and structure-activity relationships in cancer cell lines.
• Pharmaceutical Development: Serving as a key intermediate or active pharmaceutical ingredient (API) in the preclinical development of chemotherapeutic agents.
• Academic Studies: Used in university laboratories for teaching and advanced research in medicinal chemistry and pharmacology.
• Method Development: Acting as an analytical standard for the development and validation of HPLC, LC-MS, or other chromatographic methods.

Basic Information

Product Name	10,10-Dimethyl-10-Deazaaminopterin
CAS No.	80576-88-1
Molecular Formula	C₂₁H₂₅N₇O₅
Molecular Weight	455.47 g/mol
Synonyms	10,10-Dimethyldideazafolic Acid; DDATHF Analog; 10-Deazaaminopterin, 10,10-dimethyl-; NSC 127755; (2-{4-[(1RS,2RS)-2-{[2,4-Diamino-6-pteridinyl)methyl]methylamino}cyclopentyl]anilino}-2-oxoethyl)phosphonic Acid (related structure); Pteridine analog; Antifolate; DHFR Inhibitor
EINECS	Contact for details

Quality Control

Our 10,10-Dimethyl-10-Deazaaminopterin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identity confirmation by spectroscopic methods (IR, NMR) and purity determination by HPLC to ensure it meets high-grade research standards. A Certificate of Analysis (COA) detailing batch-specific results is provided with every shipment to guarantee traceability and consistency for your critical research and development work.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	Yellow to light brown powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.