Description

Edatrexate is a potent antifolate compound and a structural analog of methotrexate, designed for enhanced cellular uptake and retention. Its primary value lies in its targeted mechanism of action, which inhibits dihydrofolate reductase (DHFR) and disrupts folate metabolism, a critical pathway for DNA synthesis and cell proliferation. This makes it a compound of significant interest for pharmaceutical research and development, particularly in the fields of oncology and immunology. Researchers and manufacturers engaged in developing novel chemotherapeutic agents and studying drug resistance mechanisms are the key users of this high-purity chemical.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of advanced anticancer drug candidates.
• Oncology Research: Used as a reference standard and active compound in in vitro and in vivo studies targeting various cancer cell lines, including leukemia and solid tumors.
• Mechanism of Action Studies: Employed to investigate folate metabolism inhibition, DHFR enzyme kinetics, and the pathways of antifolate resistance.
• Biochemical Assay Development: Utilized as a key reagent in developing high-throughput screening assays for novel DHFR inhibitors.
• Comparative Drug Efficacy Research: Acts as a comparator in studies evaluating the potency and selectivity of next-generation antifolate therapies.

Basic Information

Product Name	Edatrexate
CAS No.	80576-83-6
Molecular Formula	C₂₃H₂₃N₇O₅
Molecular Weight	477.48 g/mol
Synonyms	10-Ethyl-10-deazaaminopterin; 10-EdAM; CGP-30694; NSC-626715; (2S)-2-[[4-[(2,4-Diaminopteridin-6-yl)methyl](ethyl)amino]benzoyl]amino]pentanedioic acid; Ethyl-deaza-aminopterin; Edatrexate (USAN)
EINECS	Contact for details

Quality Control

Our Edatrexate is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity suitable for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing key parameters such as identity, purity, and impurity profiles. We adhere to relevant Good Manufacturing Practice (GMP) principles for active pharmaceutical ingredients (APIs) where applicable. Certificates of Analysis (COA) are available upon request to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity. The container should be kept tightly sealed when not in use.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.