Description

10-Methyl-10-Deazaaminopterin is a high-purity, synthetic analog of aminopterin, designed for advanced research and development applications. This compound is valued for its specific biochemical activity and serves as a critical intermediate or reference standard in pharmaceutical discovery. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers engaged in oncology research and antifolate mechanism studies. Our supply ensures consistent quality and reliable availability for your most demanding projects.

Application

• Pharmaceutical Research & Development: As a key intermediate or reference standard in the synthesis and study of novel antifolate chemotherapeutic agents.
• Biochemical Research: For investigating enzyme inhibition mechanisms, particularly targeting dihydrofolate reductase (DHFR) in metabolic pathway studies.
• Oncology Drug Discovery: Used in preclinical studies to evaluate the efficacy and structure-activity relationships (SAR) of new anticancer compounds.
• Academic Research: Serves as a precise chemical tool in university and institutional labs for biochemical and pharmacological experiments.
• Fine Chemical Synthesis: Acts as a specialized building block for the custom synthesis of complex molecules and labeled compounds for tracer studies.
• Quality Control & Analytical Standards: Employed as a high-purity certified reference material (CRM) for method development and validation in analytical laboratories.

Basic Information

Product Name	10-Methyl-10-Deazaaminopterin
CAS No.	80576-77-8
Molecular Formula	C₂₀H₂₃N₇O₅
Molecular Weight	441.45 g/mol
Synonyms	10-Methyl-10-deazaaminopterin; 10-Methyl-10-DAM; NSC-354646; 4-[[(2,4-Diamino-6-pteridinyl)methyl]methylamino]benzoic acid, 10-methyl-10-deaza analog; 10-Methyl-10-deaza-aminopterin; 10-Methyl-10-deaza-4-aminofolic acid; Deazaaminopterin analog
EINECS	Contact for details

Quality Control

Our 10-Methyl-10-Deazaaminopterin is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes. We adhere to cGMP principles for the production of research-grade materials, ensuring reliability for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.