Description

Ornithine-Methotrexate is a chemically modified derivative of the antifolate agent methotrexate, conjugated with the amino acid ornithine. This modification is designed to potentially alter the pharmacokinetic profile, targeting, or solubility of the parent compound for enhanced research and development applications. It serves as a critical intermediate and reference standard for pharmaceutical R&D, particularly in oncology and immunology research. Professionals in pharmaceutical development, contract research organizations (CROs), and academic laboratories require this high-purity compound for advanced drug discovery and metabolic studies.

Application

• Pharmaceutical Research & Development: Serves as a key intermediate in the synthesis of novel targeted chemotherapeutic agents and prodrugs.
• Biochemical Research: Used as a reference standard and probe in studies investigating folate metabolism, enzyme inhibition, and amino acid-drug conjugate behavior.
• Oncology Drug Discovery: Investigated for its potential to improve the therapeutic index, reduce side effects, or enable new delivery mechanisms for methotrexate-based therapies.
• Metabolic Pathway Analysis: Employed in laboratory studies to understand the cellular uptake and processing of conjugated drug molecules.
• Analytical Standard: Essential for developing and validating analytical methods (HPLC, LC-MS) for quality control and pharmacokinetic studies of related compounds.

Basic Information

Product Name	Ornithine-Methotrexate
CAS No.	80407-73-4
Molecular Formula	C26H32N8O7
Molecular Weight	568.59 g/mol
Synonyms	Methotrexate-ornithine conjugate; L-Ornithine, N5-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-; N-((2-((2,5-Diamino-5-oxopentyl)amino)-2-oxoethyl)amino)methyl)-N-methyl-4-aminobenzoic acid (related structure); MTX-Orn; Orn-MTX; Amino acid conjugate of methotrexate
EINECS	Contact for details

Quality Control

Our Ornithine-Methotrexate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency, meeting the stringent requirements for pharmaceutical research materials. We provide full traceability and support regulatory documentation needs. Certificates of Analysis (COA) detailing purity, impurities, and analytical methods (HPLC, NMR, MS) are available for every batch upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider desiccants or an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (HPLC/MS)	Conforms
Assay (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.