Description

Lysine-Methotrexate is a chemically modified derivative of the antifolate drug methotrexate, designed for targeted therapeutic applications. This compound is engineered to enhance specificity and reduce systemic toxicity, making it a valuable tool in advanced pharmaceutical research and development. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel oncology treatments and targeted drug delivery systems.

Application

• Targeted Cancer Therapy Research: Serves as a key intermediate or active pharmaceutical ingredient (API) in the development of ligand-directed chemotherapeutic agents.
• Drug Conjugate Development: Used to create antibody-drug conjugates (ADCs) or peptide-drug conjugates for precise tumor targeting.
• Biochemical Research: Acts as a potent dihydrofolate reductase (DHFR) inhibitor in mechanistic studies of folate metabolism and cell proliferation.
• Pharmaceutical Intermediates: Employed in the synthesis of more complex, next-generation therapeutic molecules with improved pharmacokinetic profiles.
• Academic and Pre-clinical Studies: Utilized in university and institutional labs for investigating novel mechanisms of action and efficacy in disease models.

Basic Information

Product Name	Lysine-Methotrexate
CAS No.	80407-56-3
Molecular Formula	C26H35N9O7
Molecular Weight	585.62 g/mol
Synonyms	Lys-Methotrexate; Methotrexate-Lysine Conjugate; N6-[(2,4-Diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-lysine; L-Lysine, N2-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-; MTX-Lys; Lys-MTX; Folate antagonist conjugate
EINECS	Contact for details

Quality Control

Our Lysine-Methotrexate is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and stringent controls for residual solvents and impurities. Certificates of Analysis (COA) are provided with each shipment, detailing all specifications and test results to ensure compliance with your research or development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry conditions to maintain stability and purity. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	Yellow to orange powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.