Description

5-Deazaaminopterin is a synthetic folate analog and potent inhibitor of dihydrofolate reductase (DHFR). This compound is a critical research-grade biochemical for investigating folate metabolism, enzyme kinetics, and cellular proliferation pathways. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies focused on oncology and metabolic disease studies.

Application

• Biochemical Research: Used as a specific inhibitor of dihydrofolate reductase (DHFR) in enzymatic assays and metabolic pathway studies.
• Antifolate Mechanism Studies: Serves as a key tool compound for investigating the mechanisms of action and resistance of antifolate drugs.
• Cell Culture & Proliferation Assays: Employed in in vitro studies to modulate folate-dependent pathways and study effects on cell growth and division.
• Pharmaceutical Development: Acts as a reference standard or intermediate in the research and development of novel chemotherapeutic agents.
• Academic Research: Utilized in university laboratories for fundamental research in biochemistry, molecular biology, and medicinal chemistry.

Basic Information

Product Name	5-Deazaaminopterin
CAS No.	80360-09-4
Molecular Formula	C₁₉H₂₀N₈O₅
Molecular Weight	440.41 g/mol
Synonyms	5-Deaza-aminopterin; 5-Deaza-AMT; 5-DAM; N-[4-[[(2,4-Diamino-5-methyl-5-deazapteridin-6-yl)methyl]amino]benzoyl]-L-glutamic Acid; 5-Methyl-5-deazaaminopterin
EINECS	Contact for details

Quality Control

Our 5-Deazaaminopterin is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with research-grade material standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	Yellow to orange powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.