Description

Gmbs CAS NO 80307-12-6 is a high-purity chemical intermediate widely recognized for its role in bioconjugation and cross-linking applications. Its primary value lies in its ability to form stable amide bonds with primary amines, making it an essential reagent for modifying proteins, peptides, and other biomolecules. This product is critical for researchers and manufacturers in the pharmaceutical, diagnostic, and life science sectors who require reliable and efficient conjugation chemistry for developing therapeutics, assays, and advanced research tools.

Application

• Bioconjugation Reagent: Used for cross-linking proteins, antibodies, and enzymes to other molecules, nanoparticles, or solid supports.
• Diagnostic Kit Manufacturing: A key component in the production of enzyme-linked immunosorbent assays (ELISA) and other immunoassay systems.
• Antibody-Drug Conjugate (ADC) Development: Serves as a linker molecule in the synthesis of targeted cancer therapies.
• Protein Labeling and Immobilization: Facilitates the tagging of proteins with fluorophores, biotin, or other probes for detection and purification.
• Polymer and Biomaterial Modification: Used to functionalize surfaces and polymers with amine-reactive groups for biomedical applications.
• Peptide Synthesis: Employed as a building block or activating agent in solid-phase peptide synthesis (SPPS).

Basic Information

Product Name	Gmbs
CAS No.	80307-12-6
Molecular Formula	C14H12N2O8S2
Molecular Weight	400.38 g/mol
Synonyms	N-(γ-Maleimidobutyryloxy)succinimide ester; GMBS; 4-Maleimidobutyric acid N-hydroxysuccinimide ester; Succinimidyl 4-(N-maleimidomethyl)cyclohexane-1-carboxylate (common mis-assignment); γ-Maleimidobutyric acid N-hydroxysuccinimide ester; Sulfo-GMBS (related compound); MBS (similar compound); NHS ester of 4-maleimidobutyric acid
EINECS	Contact for details

Quality Control

Our Gmbs is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity assessment and NMR for structural confirmation, to ensure it meets the high standards required for sensitive life science applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation and hydrolysis. For long-term stability, store under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Solubility	Soluble in DMF, DMSO, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.