Description

5'-Deoxy-5'-Chlorothymidine 3'-(4-Nitrophenyl)Phosphate is a specialized nucleotide analog derivative, a key synthetic intermediate in advanced organic and medicinal chemistry. Its precise structure makes it a critical building block for the development of novel therapeutic agents and biochemical probes. This compound is primarily utilized by research institutions and pharmaceutical companies engaged in the synthesis of nucleoside-based drugs, antiviral compounds, and molecular biology tools.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of novel nucleoside analogs with potential antiviral or anticancer activity.
• Biochemical Research: Used in the study of enzyme mechanisms, particularly those involving kinases, phosphatases, and polymerases.
• Pro-drug Development: Serves as a masked phosphate derivative for creating cell-permeable pro-drugs of bioactive nucleoside monophosphates.
• Organic Synthesis Building Block: Employed in complex multi-step syntheses requiring a protected and activated thymidine derivative.
• Antiviral Agent Research: Investigated for its potential as a scaffold in the development of compounds targeting viral replication.

Basic Information

Product Name	5'-Deoxy-5'-Chlorothymidine 3'-(4-Nitrophenyl)Phosphate
CAS No.	80214-53-5
Molecular Formula	C16H17ClN3O8P
Molecular Weight	445.75 g/mol
Synonyms	5'-Chloro-5'-deoxythymidine 3'-(4-nitrophenyl) phosphate; 5'-Deoxy-5'-chlorothymidine 3'-(p-nitrophenyl) phosphate; Thymidine, 5'-deoxy-5'-chloro-, 3'-(4-nitrophenyl) phosphate; p-Nitrophenyl 5'-deoxy-5'-chlorothymidine 3'-phosphate; 5'-Chloro-5'-deoxy-p-nitrophenyl thymidine 3'-phosphate
EINECS	Contact for details

Quality Control

Our production of 5'-Deoxy-5'-Chlorothymidine 3'-(4-Nitrophenyl)Phosphate adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity for research and development applications. Each lot is characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture absorption, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.