Description

n-Acetyl Leukotriene E4 is a chemically modified derivative of the potent lipid mediator Leukotriene E4, characterized by the acetylation of the cysteinyl moiety. This modification enhances its stability and makes it a crucial reference standard and research tool for studying the leukotriene pathway and eicosanoid signaling. It is primarily utilized by pharmaceutical researchers, academic institutions, and diagnostic developers engaged in inflammation, allergy, and respiratory disease research.

Application

• Biochemical Research: Used as a high-purity reference standard in the study of leukotriene biosynthesis, metabolism, and receptor interactions.
• Pharmaceutical Development: Serves as a critical analytical standard in the R&D of drugs targeting asthma, allergic rhinitis, and other inflammatory conditions.
• Diagnostic Assays: Employed in the calibration and validation of immunoassays (e.g., ELISA) and LC-MS/MS methods for quantifying leukotriene metabolites in biological samples.
• Cell Signaling Studies: Applied in in vitro models to investigate the role of cysteinyl leukotrienes in cellular processes and disease mechanisms.

Basic Information

Product Name	n-Acetyl Leukotriene E4
CAS No.	80115-95-3
Molecular Formula	C25H39NO7S
Molecular Weight	497.65 g/mol
Synonyms	N-Acetyl-LTE4; Acetyl Leukotriene E4; Leukotriene E4, N-acetyl-; 5(S),6(R)-Epoxy-7(E),9(E),11(Z),14(Z)-eicosatetraenoic acid, N-acetyl-5(S)-hydroxy-6(R)-S-cysteinyl-; N-Acetyl-5(S)-hydroxy-6(R)-S-cysteinyl-7(E),9(E),11(Z),14(Z)-eicosatetraenoic acid; N-Acetyl-LTE4; LTE4 N-Acetate
EINECS	Contact for details

Quality Control

Our n-Acetyl Leukotriene E4 is produced and handled under strict quality protocols to ensure batch-to-batch consistency and high chemical purity, suitable for sensitive analytical and research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles as determined by HPLC, MS, and NMR. We adhere to ISO 9001 quality management principles in our operations.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store unopened vials at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation. Once opened, it is recommended to use the product promptly and re-purge the container with inert gas before resealing.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in ethanol, methanol; slightly soluble in aqueous buffer

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.