Description

Totaquine CAS NO 8014-53-7 is a standardized mixture of alkaloids derived from cinchona bark, primarily consisting of quinine, quinidine, cinchonine, and cinchonidine. This natural product complex is valued for its established pharmacological properties and serves as a key starting material for the isolation and synthesis of its individual bioactive components. It is essential for manufacturers in the pharmaceutical, nutraceutical, and research sectors seeking a reliable source of these classic antimalarial and antiarrhythmic compounds.

Application

• Pharmaceutical Intermediates: Serves as a critical raw material for the extraction and purification of quinine and quinidine, which are used in antimalarial and cardiac medication formulations.
• Research & Development: Used in biochemical and pharmacological studies to investigate the properties of cinchona alkaloids, their mechanisms of action, and potential new therapeutic applications.
• Nutraceutical & Dietary Supplements: Employed as a source of bitter principles in tonic formulations and other herbal supplement products.
• Chemical Synthesis: Acts as a chiral pool starting material for the synthesis of more complex molecules in organic and medicinal chemistry.
• Analytical Standards: Provides a reference mixture for the quality control and standardization of cinchona-based products in analytical laboratories.
• Bittering Agent: Utilized in the food and beverage industry, particularly in the production of bitter tonics and certain alcoholic beverages.

Basic Information

Product Name	Totaquine
CAS No.	8014-53-7
Molecular Formula	Mixture (Primarily C20H24N2O2, C20H24N2O2, C19H22N2O, C19H22N2O)
Molecular Weight	Mixture
Synonyms	Cinchona Alkaloids; Totaquina; Total Alkaloids of Cinchona; Cinchona Total Alkaloids; Quinine Mixture; Quinidine Mixture; Cinchonine-Cinchonidine Mixture; Cinchona Bark Extract (Standardized)
EINECS	Contact for details

Quality Control

Our Totaquine is produced and tested to ensure consistent composition and quality. We employ rigorous analytical methods, including HPLC and titration, to verify the total alkaloid content and the profile of key constituents like quinine and quinidine. A comprehensive Certificate of Analysis (COA) detailing assay results, identification, and purity is provided with each batch to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is kept tightly sealed to prevent absorption of atmospheric moisture.

Specification

Item	Specification
Appearance	White to pale yellowish powder
Identification (IR)	Conforms to standard
Assay (Total Alkaloids)	≥ 70.0% (by Titration)
Quinine Content	10.0% - 25.0% (by HPLC)
Quinidine Content	5.0% - 15.0% (by HPLC)
Loss on Drying	≤ 5.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.