Description

1-[12-Biotinyl(Aminododecanoyl)]-2-Hydroxy-Sn-Glycero-3-Phosphate (Ammonium Salt) is a high-purity, synthetic phospholipid derivative conjugated with biotin via a 12-carbon linker. This compound is a critical reagent for the specific labeling and isolation of membrane components in advanced biochemical research and diagnostic assay development. It is primarily utilized by researchers and manufacturers in the life sciences sector, particularly in proteomics, lipidomics, and the development of targeted drug delivery systems.

Application

• Liposome and Membrane Protein Research: As a biotinylated phospholipid for incorporating into liposomal bilayers to study membrane dynamics, protein-lipid interactions, and for affinity purification of membrane-associated complexes.
• Biosensor and Diagnostic Assay Development: Used to functionalize sensor surfaces or microplate wells to capture streptavidin/avidin-conjugated analytes, enhancing sensitivity in ELISA and other immunoassays.
• Targeted Drug Delivery Systems: Serves as a key component in the design of ligand-directed liposomal nanoparticles, where the biotin moiety enables subsequent conjugation to targeting antibodies or proteins via streptavidin bridges.
• Affinity Chromatography: Immobilized on avidin/streptavidin resins to create specialized columns for the purification of lipid-binding proteins or other biomolecules.
• Cell Biology and Imaging: Employed to label cell membranes for tracking and visualization studies using fluorescence-labeled streptavidin probes.
• Model Membrane Studies: Used in the construction of supported lipid bilayers (SLBs) to investigate fundamental biophysical properties of cell membranes.

Basic Information

Product Name	1-[12-Biotinyl(Aminododecanoyl)]-2-Hydroxy-Sn-Glycero-3-Phosphate (Ammonium Salt)
CAS No.	799812-69-4
Molecular Formula	C33H65N5O9P • xNH3
Molecular Weight	Contact for details
Synonyms	Biotinylated Phospholipid; Biotin-Cap-PE; 1-Biotinyl-2-hydroxy-sn-glycero-3-phosphoethanolamine (Ammonium Salt); Biotinyl Cap Phosphatidylethanolamine; Biotin-PE; Biotin Cap PE; N-(Biotinoyl)-N'-(12-aminododecanoyl)-1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine; Biotinyl phosphatidylethanolamine
EINECS	Contact for details

Quality Control

Our 1-[12-Biotinyl(Aminododecanoyl)]-2-Hydroxy-Sn-Glycero-3-Phosphate (Ammonium Salt) is manufactured under strict quality systems suitable for research and diagnostic use. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure consistency and reliability. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature before opening to minimize moisture condensation. For long-term storage, keep under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid or film
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Assay (Phosphorus Content)	Contact for details
Solubility	Soluble in chloroform, methanol, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.