Description

1-Oleoyl-2-(12-Biotinyl(Aminododecanoyl))-Sn-Glycero-3-Phosphoethanolamine CAS NO 799812-67-2 is a high-purity, synthetic phospholipid derivative designed for advanced biochemical and biophysical research. This compound is engineered to facilitate the specific labeling and study of membrane-associated processes by incorporating a biotin moiety for high-affinity streptavidin binding. It is an essential reagent for scientists in lipidomics, membrane biophysics, and drug delivery system development, providing a critical tool for creating functionalized liposomes and studying protein-lipid interactions.

Application

• Liposome Functionalization: Incorporation into liposomal bilayers to enable surface conjugation with streptavidin-linked targeting ligands, antibodies, or imaging probes for targeted drug delivery.
• Membrane Protein Studies: Used in the reconstitution of membrane proteins into model lipid bilayers (e.g., supported lipid bilayers, nanodiscs) for structural and functional analysis via surface plasmon resonance (SPR) or atomic force microscopy (AFM).
• Cell Surface Engineering: Facilitating the specific labeling of cell membranes for tracking, sorting, or isolation applications in flow cytometry and microscopy.
• Biosensor Development: Serving as a key component in the fabrication of lipid-based biosensor platforms for the detection of analytes that interact with membrane interfaces.
• Model Membrane Research: Creating asymmetric or complex model membranes to study lipid raft dynamics, phase separation, and the behavior of lipids in specialized microdomains.
• Diagnostic Assay Kits: Acting as a critical reagent in diagnostic kits that utilize liposome or membrane-based signal amplification techniques.

Basic Information

Item	Details
Product Name	1-Oleoyl-2-(12-Biotinyl(Aminododecanoyl))-Sn-Glycero-3-Phosphoethanolamine
CAS No.	799812-67-2
Molecular Formula	C55H100N4O10PS
Molecular Weight	1025.45 g/mol
Synonyms	Biotin Cap PE; 1-Oleoyl-2-{12-[(biotinyl)amino]dodecanoyl}-sn-glycero-3-phosphoethanolamine; Biotinyl Caproyl Phosphatidylethanolamine; Biotinylated PE; Biotin-Cap-PE; Biotin-X DHPE; N-((6-(Biotinoyl)amino)hexanoyl)-1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine (common analog name); 18:1-12:0 Biotinyl Cap PE
EINECS	Contact for details

Quality Control

Our 1-Oleoyl-2-(12-Biotinyl(Aminododecanoyl))-Sn-Glycero-3-Phosphoethanolamine is manufactured under strict quality protocols to ensure batch-to-batch consistency and high performance in sensitive applications. Each lot is characterized using advanced analytical techniques including HPLC, mass spectrometry (MS), and NMR to confirm identity, purity, and functional integrity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is easily oxidized; it is recommended to store under an inert atmosphere (argon or nitrogen) after opening and to minimize exposure to air. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid or film
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Solubility	Soluble in chloroform, methanol, DMSO; forms micelles in aqueous buffer
Functional Activity (Biotin Content)	≥ 90% of theoretical
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.