Description

1-Oleoyl-2-(12-Biotinyl(Aminododecanoyl))-Sn-Glycero-3-Phospho-L-Serine (Ammonium Salt) is a highly specialized, synthetic phospholipid derivative designed for advanced biochemical and biophysical research. This compound is critical for studying membrane-protein interactions, lipid signaling, and cellular trafficking due to its unique biotinylated and functionalized structure. It is an essential reagent for researchers in pharmaceutical development, structural biology, and advanced diagnostics who require precise, high-purity lipid probes and tools.

Application

• Liposome and Membrane Model Systems: Incorporation into liposomes and supported lipid bilayers (SLBs) for biophysical studies of membrane dynamics and protein-lipid interactions.
• Protein Binding and Pull-Down Assays: Utilized as a biotinylated lipid anchor for streptavidin/avidin-based capture and purification of membrane-associated proteins.
• Cell Signaling Research: Investigation of the role of phosphatidylserine derivatives in apoptosis, blood coagulation, and intracellular signaling pathways.
• Drug Delivery System Development: A functional component in the design of targeted liposomal drug delivery carriers for enhanced cellular uptake.
• Diagnostic Assay Development: Used in the fabrication of biosensors and diagnostic platforms that require stable, functionalized lipid surfaces.
• Structural Biology: Aiding in the crystallization and structural analysis of membrane proteins by providing a native-like lipid environment.

Basic Information

Product Name	1-Oleoyl-2-(12-Biotinyl(Aminododecanoyl))-Sn-Glycero-3-Phospho-L-Serine (Ammonium Salt)
CAS No.	799812-66-1
Molecular Formula	C55H100N5O13P
Molecular Weight	1078.4 g/mol
Synonyms	Biotinylated Phosphatidylserine; 18:1 Biotinyl Cap Phosphatidylserine; Biotinyl Cap PS; 1-Oleoyl-2-{12-[(biotinyl)amino]dodecanoyl}-sn-glycero-3-phospho-L-serine (ammonium salt); Biotinyl-Cap-PS; Biotin-PE-PS; Biotinylated PS; Biotin Cap Phosphatidyl-L-serine
EINECS	Contact for details

Quality Control

Our high-purity phospholipids are manufactured under strict quality control protocols to ensure batch-to-batch consistency and reliability for sensitive research applications. Each lot is characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry to confirm identity, purity, and functional integrity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive). For long-term storage, keep under an inert atmosphere (argon or nitrogen) to prevent oxidation. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid or film
Identification (HPLC/MS)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Solubility	Soluble in chloroform, methanol, DMSO
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.