Description

1,2-Dihexanoyl-Sn-Glycero-3-Phospho-(1'-Myo-Inositol-3',4',5'-Trisphosphate) (Ammonium Salt) is a high-purity, synthetic phospholipid derivative of phosphatidylinositol (3,4,5)-trisphosphate (PIP3). This compound serves as a critical biochemical tool and a key intermediate in the study of intracellular signaling pathways, particularly those involving the PI3K/Akt/mTOR cascade. It is essential for researchers and developers in pharmaceutical discovery, cell biology, and biochemical assay development who require precise and reliable lipid signaling molecules.

Application

• Biochemical Research & Assay Development: Used as a substrate or standard in enzymatic assays for phosphoinositide kinases (e.g., PI3K) and phosphatases.
• Cell Signaling Studies: Critical for investigating the role of PIP3 in cellular processes such as cell growth, proliferation, survival, and glucose metabolism.
• Drug Discovery Screening: Employed in high-throughput screening (HTS) platforms to identify and characterize novel inhibitors or activators of the PI3K pathway, a major target in oncology.
• Lipidomics & Metabolomics: Serves as a reference standard for the identification and quantification of complex phosphoinositides in mass spectrometry-based lipidomic analyses.
• Membrane Biophysics: Used in the preparation of model membranes (liposomes, lipid bilayers) to study protein-lipid interactions and membrane dynamics.
• Production of Lipidated Peptides/Proteins: Acts as a precursor or intermediate for the synthesis of more complex, site-specifically lipidated biomolecules for therapeutic or diagnostic applications.

Basic Information

Product Name	1,2-Dihexanoyl-Sn-Glycero-3-Phospho-(1'-Myo-Inositol-3',4',5'-Trisphosphate) (Ammonium Salt)
CAS No.	799268-62-5
Molecular Formula	C27H55N4O24P4 (Ammonium Salt)
Molecular Weight	~898.66 g/mol (Free acid form, contact for exact salt form weight)
Synonyms	PI(3,4,5)P3 (C6:0); DiC6 PI(3,4,5)P3; 1,2-Dihexanoyl Phosphatidylinositol (3,4,5)-Trisphosphate; Dihexanoyl PIP3; PtdIns(3,4,5)P3 (DiC6); 1,2-Dihexanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate); Ammonium Salt of PIP3 (C6:0)
EINECS	Contact for details

Quality Control

Our high-purity biochemical lipids are manufactured under strict quality systems. Each batch undergoes comprehensive analytical characterization to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided, typically including data from NMR, mass spectrometry, and HPLC. We support research requiring GMP-grade materials and can tailor specifications to meet specific project needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, consider under an inert atmosphere. Allow the vial to reach room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid or film
Identification (NMR)	Complies with structure
Identification (MS)	Complies with structure
Purity (HPLC)	≥ 95% (Area %)
Assay (Phosphorus)	≥ 85% (by weight)
Solubility	Soluble in chloroform/methanol/water mixtures
Water Content (KF)	< 5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.