Description

1-Stearoyl-2-Arachidonoyl-Sn-Glycero-3-Phospho-(1'-Myo-Inositol-3',4',5'-Trisphosphate) (Ammonium Salt) is a highly specialized, biologically active phosphoinositide lipid derivative, critical for cellular signaling research. This compound serves as a vital tool for studying the intricate mechanisms of intracellular signal transduction pathways, particularly those involving phosphatidylinositol (3,4,5)-trisphosphate (PIP3). It is essential for researchers and developers in pharmaceutical discovery, biochemical assay development, and advanced cell biology, where precise molecular probes are required to elucidate disease mechanisms and identify novel therapeutic targets.

Application

• Biochemical Research & Assay Development: Used as a standard, substrate, or ligand in enzymatic assays to study the activity and inhibition of kinases, phosphatases, and phospholipases involved in phosphoinositide signaling.
• Pharmaceutical Discovery: Serves as a key molecular tool for high-throughput screening (HTS) to identify and validate new drug candidates targeting the PI3K/Akt/mTOR and other related signaling pathways.
• Cell Signaling Studies: Employed in lipidomics and cell biology research to investigate the role of specific phosphoinositides in processes like cell growth, proliferation, survival, and vesicular trafficking.
• Lipid-Protein Interaction Analysis: Utilized in surface plasmon resonance (SPR), isothermal titration calorimetry (ITC), and other biophysical techniques to characterize binding affinities with PH domains and other lipid-binding proteins.
• Diagnostic Reagent Manufacturing: Acts as a critical raw material in the production of specialized diagnostic kits and reagents for research into cancer, metabolic disorders, and immune diseases.
• Academic & Institutional Research: Provides a defined, high-purity compound for fundamental research in universities and government laboratories focused on signal transduction.

Basic Information

Product Name	1-Stearoyl-2-Arachidonoyl-Sn-Glycero-3-Phospho-(1'-Myo-Inositol-3',4',5'-Trisphosphate) (Ammonium Salt)
CAS No.	799268-60-3
Molecular Formula	C47H85N2O22P4 (Ammonium Salt)
Molecular Weight	~1157.1 g/mol (Free acid form, contact for exact salt form weight)
Synonyms	PIP3 (18:0/20:4)
Phosphatidylinositol (3,4,5)-trisphosphate (PIP3) (1-Stearoyl-2-Arachidonoyl)
PtdIns(3,4,5)P3 (18:0/20:4)
1-Octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) ammonium salt
PI(3,4,5)P3 (18:0/20:4)
L-α-Phosphatidylinositol-3,4,5-trisphosphate (Stearoyl, Arachidonoyl)
Cell Signaling Lipid (PIP3, specific acyl chain)
EINECS	Contact for details

Quality Control

Every batch of our high-purity lipid derivatives is manufactured and analyzed under strict quality protocols. Certificates of Analysis (COA) are provided, detailing comprehensive testing via HPLC, MS, and NMR to confirm identity, purity, and acyl chain composition. Our production adheres to cGMP guidelines where applicable, ensuring consistency and reliability for critical research applications. We are committed to supplying materials that meet the exacting standards of the global life science research community.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere (argon or nitrogen). This product is hygroscopic (moisture-sensitive) and easily oxidized; allow the vial to equilibrate to room temperature in a desiccator before opening to minimize exposure to moisture and air. Aliquot into single-use vials upon receipt to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white solid or film
Identification (HPLC/MS)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95% (Area %)
Assay (Phosphorus Content)	≥ 98% of theoretical
Acyl Chain Composition	Conforms (Stearoyl & Arachidonoyl)
Solubility	Soluble in chloroform/methanol/water mixtures
Water Content (KF)	< 2.0 %

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.