Description

1-Stearoyl-2-Arachidonoyl-Sn-Glycero-3-Phospho-(1'-Myo-Inositol-4',5'-Bisphosphate) (Ammonium Salt) is a high-purity, synthetic phospholipid derivative, specifically a phosphatidylinositol 4,5-bisphosphate (PIP2) species with defined acyl chains. This compound is a critical signaling molecule and substrate in biochemical research, enabling the study of cellular processes such as signal transduction, membrane trafficking, and cytoskeletal dynamics. It is essential for pharmaceutical R&D, academic research institutions, and diagnostic developers focused on lipid metabolism, phosphoinositide pathways, and related drug discovery.

Application

• Biochemical Research & Assay Development: Used as a standard or substrate in enzymatic assays for kinases (e.g., PI3K), phosphatases, and phospholipases.
• Cell Signaling Studies: Essential for investigating intracellular signaling cascades mediated by phosphoinositides, including calcium mobilization and protein recruitment.
• Lipidomics & Analytical Standards: Serves as a critical reference standard in mass spectrometry (LC-MS, MS/MS) for the identification and quantification of complex cellular lipids.
• Drug Discovery Platforms: Employed in high-throughput screening (HTS) to identify modulators of phosphoinositide-binding proteins and enzymes as potential therapeutic targets.
• Membrane Biophysics: Used in model membrane systems (e.g., liposomes, lipid bilayers) to study protein-lipid interactions and membrane domain formation.
• Diagnostic Reagent Formulation: A potential component in specialized diagnostic kits for monitoring specific metabolic or signaling pathway activities.

Basic Information

Product Name	1-Stearoyl-2-Arachidonoyl-Sn-Glycero-3-Phospho-(1'-Myo-Inositol-4',5'-Bisphosphate) (Ammonium Salt)
CAS No.	799268-59-0
Molecular Formula	C47H85NO22P3 • xNH3
Molecular Weight	~1132.10 (Free acid, approximate)
Synonyms	PIP2 (18:0-20:4); PI(4,5)P2 (18:0/20:4); Phosphatidylinositol 4,5-bisphosphate (SAPC); 1-Stearoyl-2-arachidonoyl-phosphatidylinositol-4,5-bisphosphate ammonium salt; L-α-Phosphatidylinositol-4,5-bisphosphate (18:0/20:4); PtdIns(4,5)P2 (18:0-20:4); (3-sn-Phosphatidyl)-1D-myo-inositol 4,5-bisphosphate (1-stearoyl-2-arachidonoyl) ammonium salt
EINECS	Contact for details

Quality Control

Our high-purity lipid products are manufactured under strict quality management systems. Each batch of 1-Stearoyl-2-Arachidonoyl-Sn-Glycero-3-Phospho-(1'-Myo-Inositol-4',5'-Bisphosphate) (Ammonium Salt) undergoes rigorous analytical testing, including HPLC, MS, and NMR, to confirm identity, purity, and acyl chain composition. Certificates of Analysis (COA) detailing lot-specific results are provided to ensure reproducibility and reliability for your critical research and development work.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere. The product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white solid or film
Identification (MS)	Complies
Identification (NMR)	Complies
Purity (HPLC)	≥ 95%
Solvent Content (Residual)	≤ 2.0%
Acyl Chain Composition (GC)	Confirms 18:0 & 20:4

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.