Description

1-Stearoyl-2-Arachidonoyl-Sn-Glycero-3-Phospho-(1'-Myo-Inositol-3',5'-Bisphosphate) (Ammonium Salt) is a high-purity, synthetic phospholipid derivative, specifically a phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2) species. This compound is a critical signaling lipid and research-grade biochemical used to study intracellular membrane trafficking, endosomal dynamics, and ion channel regulation. It is essential for researchers and developers in academic research, pharmaceutical discovery, and biotechnology who require precise molecular tools to investigate phosphoinositide-mediated signaling pathways.

Application

• Biochemical Research: As a standard and substrate for studying enzymes like phosphatidylinositol kinases and phosphatases.
• Cell Signaling Studies: Investigation of PI(3,5)P2's role in cellular processes such as autophagy, endosome maturation, and osmotic stress response.
• Lipidomics & Mass Spectrometry: Use as an internal standard or reference compound for the quantitative analysis of complex lipid samples.
• Membrane Biophysics: Incorporation into artificial lipid bilayers or liposomes to study protein-lipid interactions and membrane curvature.
• Drug Discovery Screening: Target compound in high-throughput assays to identify modulators of phosphoinositide signaling pathways for therapeutic development.
• Diagnostic Reagent Development: Potential component in assay kits designed to detect or quantify specific lipid-protein interactions.

Basic Information

Product Name	1-Stearoyl-2-Arachidonoyl-Sn-Glycero-3-Phospho-(1'-Myo-Inositol-3',5'-Bisphosphate) (Ammonium Salt)
CAS No.	799268-58-9
Molecular Formula	C47H85NO19P3 • xNH3
Molecular Weight	~1084.10 (Free acid, anhydrous basis)
Synonyms	PI(3,5)P2 (18:0/20:4); Phosphatidylinositol 3,5-bisphosphate (SAP); 1-Stearoyl-2-arachidonoyl-phosphatidylinositol 3,5-bisphosphate ammonium salt; PtdIns(3,5)P2; 1-Octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) ammonium salt; Dipalmitoyl PI(3,5)P2 (common misnomer); PIP2(3,5); L-α-Phosphatidylinositol-3,5-bisphosphate (18:0/20:4)
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards for research chemicals. Each batch is characterized using advanced analytical techniques to confirm identity, purity, and lipid composition. Certificates of Analysis (COA) detailing lot-specific results from NMR, MS, and HPLC analyses are available upon request. We adhere to a quality management system to ensure traceability and consistency for critical research applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage under inert atmosphere, seal under argon or nitrogen after opening. Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid or film
Identification (NMR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95% (Area %)
Assay (Phosphorus)	≥ 98% (on anhydrous solvent-free basis)
Solvent Content (Residual Solvent)	≤ 2% (by 1H NMR or KF)
Fatty Acid Composition (GC)	Stearic acid (C18:0) & Arachidonic acid (C20:4) predominant
Ammonium Content	As specified per batch

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.