Description

1,2-Dioleoyl-Sn-Glycero-3-Phospho-(1'-Myo-Inositol-3',4',5'-Trisphosphate) (Ammonium Salt) is a high-purity, synthetic phospholipid derivative of phosphatidylinositol (3,4,5)-trisphosphate (PIP3). This compound is a critical signaling lipid and serves as a key reagent in biochemical and cell biology research for studying intracellular signaling pathways, particularly those involving the PI3K/Akt/mTOR cascade. It is essential for researchers and developers in pharmaceutical discovery, lipidomics, and membrane biophysics who require well-defined, bioactive lipid standards and tools. The ammonium salt form enhances solubility in aqueous systems for experimental applications.

Application

• Biochemical Research: As a standard and substrate for studying phosphoinositide 3-kinase (PI3K) signaling, protein-lipid interactions, and enzyme kinetics.
• Liposome & Drug Delivery Formulation: Incorporated into liposomal membranes to create bioactive nanoparticles for targeted drug delivery and cellular uptake studies.
• Cell Biology Studies: Used in cellular assays to investigate the role of PIP3 in cell growth, proliferation, survival, and cytoskeletal reorganization.
• Pharmaceutical Screening: Serves as a key component in high-throughput screening assays to identify novel inhibitors or activators of the PI3K pathway.
• Lipidomics Reference Standard: An essential certified reference material for the accurate identification and quantification of phosphoinositides in complex biological samples via mass spectrometry.
• Membrane Protein Research: Used to create defined lipid bilayers for the functional reconstitution and study of membrane-associated proteins and domains (e.g., PH domains).

Basic Information

Product Name	1,2-Dioleoyl-Sn-Glycero-3-Phospho-(1'-Myo-Inositol-3',4',5'-Trisphosphate) (Ammonium Salt)
CAS No.	799268-57-8
Molecular Formula	C51H95NO22P4 • xNH3
Molecular Weight	~1158.2 g/mol (Free acid, approximate)
Synonyms	PI(3,4,5)P3 (18:1); DOPI(3,4,5)P3; 1,2-Dioleoyl-*sn*-glycero-3-phospho-(1D-*myo*-inositol-3,4,5-trisphosphate) ammonium salt; Phosphatidylinositol 3,4,5-trisphosphate (Dioleoyl); PIP3 (18:1/18:1); (3,4,5)-PIP3; DOPI(3,4,5)P3 ammonium salt; 1,2-Di-(9Z-octadecenoyl)-*sn*-glycero-3-phospho-(1D-*myo*-inositol-3,4,5-trisphosphate) ammonium salt
EINECS	Contact for details

Quality Control

Every batch of our high-purity lipid products is manufactured and analyzed under strict quality protocols. We guarantee identity, purity, and functional integrity through comprehensive analytical techniques including HPLC, NMR, and mass spectrometry. A detailed Certificate of Analysis (COA) providing batch-specific data for identity, assay purity, and impurity profiles is supplied with each product to ensure reproducibility and reliability for your critical research and development work.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive) and easily oxidized; it is recommended to store under an inert atmosphere (argon or nitrogen) and allow the vial to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid or film
Identification (HPLC/MS)	Conforms to reference standard
Assay (Purity, HPLC)	≥ 95% (Area %)
Solubility	Soluble in chloroform/methanol mixtures; forms dispersions in aqueous buffer
Heavy Metals	< 10 ppm
Residual Solvents	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.