Description

1,2-Dioleoyl-Sn-Glycero-3-Phospho-(1'-Myo-Inositol-4',5'-Bisphosphate) (Ammonium Salt) is a high-purity, synthetic phospholipid derivative of phosphatidylinositol 4,5-bisphosphate (PIP2), a critical signaling molecule in cellular processes. Its primary value lies in its use as a key research reagent and a vital component in lipid-based formulations for studying membrane biology and signal transduction pathways. This compound is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and life science research sectors who require well-defined, high-quality lipids for drug delivery systems, cell signaling studies, and biochemical assays.

Application

• Liposome and Lipid Nanoparticle (LNP) Formulation: As a functional, anionic phospholipid component for creating targeted drug delivery vehicles, including mRNA vaccines and cancer therapeutics.
• Biochemical Research: As a substrate or standard for studying enzymes like phospholipase C (PLC) and phosphoinositide 3-kinases (PI3Ks) in cell signaling cascades.
• Membrane Biophysics Studies: For constructing model lipid bilayers and giant unilamellar vesicles (GUVs) to investigate protein-lipid interactions and membrane dynamics.
• Cell Biology Assays: Used in cellular transfection reagents and to replenish or manipulate PIP2 levels in cell membranes to study its role in cytoskeletal organization, endocytosis, and ion channel regulation.
• Pharmaceutical Intermediate: As a specialized raw material in the development of advanced therapeutic medicinal products (ATMPs) and other lipid-based pharmaceuticals.
• Diagnostic Reagent Production: As a critical component in the development of diagnostic kits for diseases involving phosphoinositide signaling pathways.

Basic Information

Product Name	1,2-Dioleoyl-Sn-Glycero-3-Phospho-(1'-Myo-Inositol-4',5'-Bisphosphate) (Ammonium Salt)
CAS No.	799268-56-7
Molecular Formula	C47H88NO19P3 • xNH3
Molecular Weight	~1080.1 g/mol (free acid, approximate)
Synonyms	PIP2 (18:1); PI(4,5)P2 (dioleoyl); 1,2-Dioleoyl-sn-glycero-3-phosphoinositol 4,5-bisphosphate ammonium salt; DOPI(4,5)P2 ammonium salt; Phosphatidylinositol 4,5-bisphosphate (18:1); (3-sn-Phosphatidyl)-1D-myo-inositol 4,5-bisphosphate (dioleoyl); L-α-Phosphatidylinositol-4,5-bisphosphate (Dioleoyl); Avanti Polar Lipids Catalog No. 850155
EINECS	Contact for details

Quality Control

Our 1,2-Dioleoyl-Sn-Glycero-3-Phospho-(1'-Myo-Inositol-4',5'-Bisphosphate) (Ammonium Salt) is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing including HPLC for purity, MS for identity confirmation, and NMR for structural verification to ensure compliance with research-grade specifications. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing batch-specific results for identity, purity, and critical impurities. Our quality commitment supports applications requiring high reproducibility and traceability in pharmaceutical research and development.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. Upon receipt, the product should be stored desiccated. Allow the vial to warm to room temperature before opening to prevent condensation and moisture ingress. For optimal results, aliquot into single-use vials under inert conditions to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white solid or waxy solid
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 97% (Area %)
Solubility	Soluble in chloroform/methanol mixtures; forms micelles in aqueous buffer
Residual Solvents (GC)	Meets ICH guidelines
Water Content (KF)	≤ 2.0 %

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.