Description

1,2-Dioleoyl-Sn-Glycero-3-Phospho-(1'-Myo-Inositol-3',4'-Bisphosphate) (Ammonium Salt) is a high-purity, synthetic phospholipid derivative, specifically a phosphoinositide, essential for advanced life science research and pharmaceutical development. This compound serves as a critical signaling lipid and membrane component, enabling the study of intracellular pathways, membrane trafficking, and lipid-protein interactions. It is primarily utilized by researchers and manufacturers in biotechnology, pharmaceutical R&D, and advanced cell biology for applications such as liposome formulation, drug delivery systems, and mechanistic studies of cellular signaling networks.

Application

• Lipid Signaling Research: As a source of PI(3,4)P2 (phosphatidylinositol 3,4-bisphosphate) for studying its role in cell growth, survival, and endocytosis.
• Liposome & Nanoparticle Formulation: A key phospholipid component for creating specialized liposomes and lipid nanoparticles (LNPs) for targeted drug and gene delivery.
• Membrane Biophysics Studies: Used to create model membranes (e.g., supported lipid bilayers, vesicles) to investigate lipid-protein interactions and membrane dynamics.
• Enzyme Substrate: Serves as a specific substrate for kinases, phosphatases, and phospholipases in enzymatic assays and inhibitor screening.
• Cell Culture & Transfection: Incorporated into lipid mixtures to enhance transfection efficiency or modulate cellular responses in vitro.
• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for quality control and analytical method development in drug discovery.

Basic Information

Product Name	1,2-Dioleoyl-Sn-Glycero-3-Phospho-(1'-Myo-Inositol-3',4'-Bisphosphate) (Ammonium Salt)
CAS No.	799268-54-5
Molecular Formula	C47H88NO19P3 • xNH3
Molecular Weight	~1080.10 g/mol (free acid, approximate)
Synonyms	PI(3,4)P2 (18:1); DOPI(3,4)P2; 1,2-Dioleoyl-sn-glycero-3-phospho-(1'-myo-inositol-3',4'-bisphosphate); Phosphatidylinositol 3,4-bisphosphate (18:1); Ammonium Salt of PI(3,4)P2; DOPI(3,4)P2 Ammonium Salt; 1,2-Di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) ammonium salt
EINECS	Contact for details

Quality Control

Our high-purity phospholipids are manufactured under strict quality control protocols to ensure batch-to-batch consistency and reliability for sensitive research applications. Each lot is characterized using advanced analytical techniques including HPLC, MS, and NMR to confirm identity, purity, and lipid composition. A comprehensive Certificate of Analysis (COA) detailing purity, solvent content, and functional integrity is provided with every shipment, supporting compliance with GLP and ISO 9001 standards.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen). The product is hygroscopic (moisture-sensitive) and easily oxidized; allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation. Once opened, purge the container with inert gas and reseal immediately.

Specification

Item	Specification
Appearance	White to off-white solid or waxy solid
Identification (HPLC/MS)	Complies
Purity (HPLC)	≥ 97% (Area %)
Solvent Content (Residual Solvents)	< 2% (by NMR or GC)
Fatty Acid Composition	≥ 95% 18:1 (Oleoyl)
Water Content (Karl Fischer)	< 1.0%
Phosphorus Content	Complies with theoretical value

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.